Plasma EBV DNA clearance rate as a novel prognostic marker for metastatic/recurrent nasopharyngeal carcinoma
| Autor: | Jeffrey Y.C. Chao, Rong-San Jiang, Kai-Li Liang, Jian-Sheng Jan, Ching Te Wu, Kuan Wen Chen, Jin Ching Lin, Hsin Hong Chen, Wen-Yi Wang, Chih Wen Twu |
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| Rok vydání: | 2010 |
| Předmět: |
Cancer Research
medicine.medical_specialty Herpesvirus 4 Human Metabolic Clearance Rate medicine.medical_treatment medicine.disease_cause Gastroenterology Herpesviridae Metastasis Internal medicine Blood plasma medicine Humans Neoplasm Metastasis Chemotherapy business.industry Cancer Nasopharyngeal Neoplasms medicine.disease Prognosis Chemotherapy regimen Real-time polymerase chain reaction Oncology Nasopharyngeal carcinoma Immunology DNA Viral business |
| Zdroj: | Clinical cancer research : an official journal of the American Association for Cancer Research. 16(3) |
| ISSN: | 1557-3265 |
| Popis: | Purpose: To investigate the prognostic effect of the concentrations and clearance rates of plasma EBV DNA in metastatic/recurrent nasopharyngeal carcinoma (NPC). Experimental Design: Thirty relapsed and four previously nontreated metastatic NPC patients were treated according to the consensus guidelines of the head and neck cancer team in our hospital (i.v. chemotherapy first, followed by local irradiation boost and oral maintenance chemotherapy where applicable). Multiple plasma samples were collected during the first month of chemotherapy. Circulating EBV DNA concentrations were measured by a real-time quantitative PCR. The half-life values (t1/2) of plasma EBV DNA clearance were calculated. The associations between clinical outcome and plasma EBV DNA assays were analyzed. Results: Tumor response evaluated after 12 weeks of treatment showed 14 complete responses (41.2%), 12 partial responses (35.3%), 7 stable diseases (20.6%), and 1 progression disease (2.9%). The plasma EBV DNA concentrations have no significant effects on outcome prediction. The t1/2 of plasma EBV DNA clearance ranged from 1.85 to 28.29 days (median, 3.99). Patients with a short t1/2 of plasma EBV DNA clearance have significantly higher complete response rate and overall survival than those with long t1/2. Multivariate analysis revealed a significant effect of the t1/2 of plasma EBV DNA clearance on survival. Conclusions: The clearance rates of plasma EBV DNA during the first month of chemotherapy can predict tumor response and patient survival. Early change of chemotherapy regimen may be considered for patients with slow plasma EBV DNA clearance rate. Clin Cancer Res; 16(3); 1016–24 |
| Databáze: | OpenAIRE |
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