Cardiovascular and Catecholamine Changes After Administration of Pancuronium in Distressed Neonates

Autor:	L A, Cabal, B, Siassi, R, Artal, F, Gonzalez, J, Hodgman, C, Plajstek
Rok vydání:	1985
Předmět:	Male Respiratory Distress Syndrome Newborn Partial Pressure Infant Newborn Blood Pressure Carbon Dioxide Cardiovascular System Oxygen Catecholamines Heart Rate Pediatrics Perinatology and Child Health Humans Female Pancuronium
Zdroj:	Pediatrics. 75:284-287
ISSN:	1098-4275 0031-4005
DOI:	10.1542/peds.75.2.284
Popis:	Heart rate, blood pressure, transcutaneous gases, and catecholamine changes following intravenous injection of pancuronium were evaluated in seven ill newborn infants (birth weight: 1,280 to 4,500 g; gestational age, 29 to 42 weeks). Each infant was monitored continuously for 30 minutes before and 50 minutes after infusion of the paralyzing agent. There were no significant changes in transcutaneous gases, whereas significant increases in heart rate; systolic, diastolic, and mean blood pressures; and blood norepinephrine and epinephrine levels were found. The increase in heart rate lasted for 30 minutes, and the increase in blood pressure persisted for 50 minutes after administration of the drug. Because of the potential relationship between increased blood pressure and intraventricular hemorrhage and myocardial dysfunction, heart rate and blood pressure must be monitored during infusion of pancuronium in distressed newborns. These data suggest that pancuronium stimulates sympathetic activity in distressed newborns.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77c1782b7ce39ffe613b19f6b66a45d5 https://doi.org/10.1542/peds.75.2.284 Zobrazit plný text záznamu