Vaccination with human alphapapillomavirus-derived L2 multimer protects against human betapapillomavirus challenge, including in epidermodysplasia verruciformis model mice
| Autor: | Pola Olczak, Margaret Wong, Hua-Ling Tsai, Hao Wang, Reinhard Kirnbauer, Andrew J. Griffith, Paul F. Lambert, Richard Roden |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Skin Neoplasms
Immune Sera Papillomavirus Infections Vaccination Uterine Cervical Neoplasms Receptors Fc Alphapapillomavirus Mice Virology Epidermodysplasia Verruciformis Carcinoma Squamous Cell Animals Betapapillomavirus Humans Capsid Proteins Female Papillomavirus Vaccines Rabbits Vaccines Virus-Like Particle |
| Zdroj: | Virology. 575 |
| ISSN: | 1096-0341 |
| Popis: | Human alphapapillomaviruses (αHPV) infect genital mucosa, and a high-risk subset is a necessary cause of cervical cancer. Licensed L1 virus-like particle (VLP) vaccines offer immunity against the nine most common αHPV associated with cervical cancer and genital warts. However, vaccination with an αHPV L2-based multimer vaccine, α11-88x5, protected mice and rabbits from vaginal and skin challenge with diverse αHPV types. While generally clinically inapparent, human betapapillomaviruses (βHPV) are possibly associated with cutaneous squamous cell carcinoma (CSCC) in epidermodysplasia verruciformis (EV) and immunocompromised patients. Here we show that α11-88x5 vaccination protected wild type and EV model mice against HPV5 challenge. Passive transfer of antiserum conferred protection independently of Fc receptors (FcR) or Gr-1+ phagocytes. Antisera demonstrated robust antibody titers against ten βHPV by L1/L2 VLP ELISA and neutralized and protected against challenge by 3 additional βHPV (HPV49/76/96). Thus, unlike the licensed vaccines, α11-88x5 vaccination elicits broad immunity against αHPV and βHPV. |
| Databáze: | OpenAIRE |
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