IPM chemotherapy in cytokine refractory renal cell cancer
| Autor: | R T D Oliver, Jeremy P.C. Steele, Wendy Ansell, Jonathan Shamash, Peter Wilson, Maria L. Nystrom |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Survival Mitomycin medicine.medical_treatment cisplatin Irinotecan Gastroenterology Clinical renal cell carcinoma (RCC) Renal cell carcinoma Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Neoplasm Metastasis Infusions Intravenous Carcinoma Renal Cell Aged Chemotherapy Performance status Cytokine Therapy business.industry Middle Aged medicine.disease Symptomatic relief Kidney Neoplasms Surgery Treatment Outcome Oncology Drug Resistance Neoplasm Injections Intravenous Disease Progression Camptothecin Female business Progressive disease medicine.drug Kidney disease |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| DOI: | 10.1038/sj.bjc.6600934 |
| Popis: | Renal cell carcinoma (RCC) is notoriously chemoresistant. Current management of metastatic disease usually includes immunological agents of which the most clearly evaluated is alpha interferon. Following the failure of such agents no clear second-line therapy exists. The use of a novel combination of cisplatin, irinotecan and mitomycin may offer some palliative benefit in this situation. Thirty-three patients with cytokine refractory RCC and documented progression and documented active progressive disease with performance status 0-3 were enrolled. Therapy consisted of cisplatin 40 mg m(-2) on day 1 and day 15, irinotecan 100 mg m(-2) on day 1 and day 15, and mitomycin 6 mg m(-2) on day 1 of a 28-day cycle. The results showed that one patient (3%) had a partial response, eight (24%) had minor responses and nine (27%) had stable disease, overall 61% had symptomatic responses. Quality-of-life (QOL) assessment did not change significantly during therapy. Seventy-one percent of those who had primary refractory disease to cytokine therapy subsequently responded to IPM. The median progression-free interval was 4.8 months in this cohort on chemotherapy, compared to 3.9 months with their previous cytokine treatment. In conclusion, IPM produced symptomatic relief for a majority of patients with cytokine refractory RCC without any deterioration in QOL. Disease stabilisation on radiological assessment and symptomatic improvement were associated with prolonged survival. A degree of non-crossresistance to cytokine therapy was seen. IPM may be considered in patients with renal cancer following failure of cytokines. |
| Databáze: | OpenAIRE |
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