Nanoscale dose deposition in cell structures under X-ray irradiation treatment assisted with nanoparticles: An analytical approach to the relative biological effectiveness
| Autor: | Valery Chernov, W. Melo-Bernal, G. Chernov, M. Barboza-Flores |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Radiation-Sensitizing Agents
Materials science Cell Survival Binding energy Analytical chemistry Metal Nanoparticles Nanoparticle 02 engineering and technology Radiation Dosage Models Biological Radiation Tolerance 030218 nuclear medicine & medical imaging Ionizing radiation 03 medical and health sciences 0302 clinical medicine Neoplasms Tumor Cells Cultured Relative biological effectiveness Humans Deposition (phase transition) Computer Simulation Irradiation Nanoscopic scale Radiation X-Rays Dose-Response Relationship Radiation Radius 021001 nanoscience & nanotechnology Cellular Structures 0210 nano-technology Monte Carlo Method Relative Biological Effectiveness |
| Zdroj: | Applied Radiation and Isotopes. 138:50-55 |
| ISSN: | 0969-8043 |
| Popis: | In this study, an analytical model for the assessment of the modification of cell culture survival under ionizing radiation assisted with nanoparticles (NPs) is presented. The model starts from the radial dose deposition around a single NP, which is used to describe the dose deposition in a cell structure with embedded NPs and, in turn, to evaluate the number of lesions formed by ionizing radiation. The model is applied to the calculation of relative biological effectiveness values for cells exposed to 0.5 mg/g of uniformly dispersed NPs with a radius of 10 nm made of Fe, I, Gd, Hf, Pt and Au and irradiated with X-rays of energies 20 keV higher than the element K-shell binding energy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect