Clinical Comparison between Paclitaxel Liposome (Lipusu®) and Paclitaxel for Treatment of Patients with Metastatic Gastric Cancer
| Autor: | Ya-Dong Qian, Xin-En Huang, Xu Xu, Huan-Qin Xu, Jin Xiang, Lin Wang |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Oncology Cancer Research medicine.medical_specialty Organoplatinum Compounds Paclitaxel Epidemiology Nausea medicine.medical_treatment Adenocarcinoma Gastroenterology Tegafur chemistry.chemical_compound Stomach Neoplasms Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Aged Neoplasm Staging Retrospective Studies Chemotherapy business.industry Public Health Environmental and Occupational Health Combination chemotherapy Middle Aged Prognosis Paclitaxel Liposome Oxaliplatin chemistry Fluorouracil Liposomes Carcinoma Squamous Cell Female medicine.symptom business Follow-Up Studies medicine.drug |
| Zdroj: | Asian Pacific Journal of Cancer Prevention. 14:2591-2594 |
| ISSN: | 1513-7368 |
| Popis: | Aim: To compare the efficacy and safety of paclitaxel liposome (Lipusu ® ) with paclitaxel in combination with tegafur and oxaliplatin in treating patients with advanced gastric cancer. Materials and Methods: Patients with advanced gastric cancer receiving chemotherapy were retrospectively collected, and divided into two groups. Patients in group A received paclitaxel liposomes at a dose of 135 mg/m 2 on day 1 of each cycle, and patients in group B were given paclitaxel at the same dose with the same timing. All patients received tegafur at a dose of 500 mg mg/m 2 on days 1-5, and oxaliplatin at a dose of 80-100 mg/m 2 on day 1 for 2 cycles (each cycle was 21 d in total). Results: Fifty-eight patients could be evaluated for efficacy. The overall response rate was 47% in group A (14/30), and 46% in group B (13/28). Disease control rate was 73% in group A (22/30), and 71% in group B (20/28) (P>0.05). No significant differences were detected in hematologic and neurologic toxicities between the two groups (P>0.05). However, nausea, vomiting and hypersensitive reactions were significantly lower in group A than in group B (P |
| Databáze: | OpenAIRE |
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