Hashimoto encephalopathy: Neurological and psychiatric perspective
| Autor: | D.M. Pavlović, Aleksandra M. Pavlović, Maja Lačković |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Autoimmune disease
antithyroid antibodies medicine.medical_specialty Hashimoto encephalopathy biology business.industry corticosteroid therapy Encephalopathy Brain cortex Disease medicine.disease General Biochemistry Genetics and Molecular Biology neuropsychiatric manifestations Cerebrospinal fluid lcsh:Biology (General) Corticosteroid therapy Antigen medicine biology.protein Antibody General Agricultural and Biological Sciences Psychiatry business lcsh:QH301-705.5 |
| Zdroj: | Archives of Biological Sciences, Vol 61, Iss 3, Pp 383-394 (2009) |
| ISSN: | 1821-4339 0354-4664 |
| Popis: | Hashimoto encephalopathy (HE) is an autoimmune disease with neurological and neuropsychiatric manifestations and elevated titers of antithyroid antibodies in serum and cerebrospinal fluid. Patients are mostly women. Age varies from 8 to 86 years. Prevalence of HE is estimated to be 2.1/100,000. Neurological and/or psychiatric symptoms and signs constitute the clinical picture. The disease responds well to corticosteroid therapy, but sometimes other immunomodulatory therapies must be applied. Autoimmune mechanisms with antibodies against antigens in the brain cortex are suspected. The course of the disease can be acute, subacute, chronic, or relapsing/remitting. Some patients improve spontaneously, but a few died in spite of adequate therapy. |
| Databáze: | OpenAIRE |
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