DNA Double-Strand Break Repair: All Roads Lead to HeterochROMAtin Marks
| Autor: | Sophie E. Polo, Enrico Pobega, Pierre Caron |
|---|---|
| Přispěvatelé: | Centre épigénétique et destin cellulaire (EDC (UMR_7216)), Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP) |
| Rok vydání: | 2021 |
| Předmět: |
Euchromatin
Heterochromatin DNA repair [SDV]Life Sciences [q-bio] genetic processes Review Biology QH426-470 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Genetics chromatin remodeling factors histone variants Genetics (clinical) 030304 developmental biology 0303 health sciences histone modifications fungi heterochromatin DNA double-strand break repair pathway choice Epigenome Double Strand Break Repair Cell biology Chromatin enzymes and coenzymes (carbohydrates) Histone chemistry chromatin mobility 030220 oncology & carcinogenesis biology.protein Molecular Medicine biological phenomena cell phenomena and immunity DNA |
| Zdroj: | Frontiers in Genetics Frontiers in Genetics, Frontiers, 2021, 12, ⟨10.3389/fgene.2021.730696⟩ Frontiers in Genetics, Vol 12 (2021) |
| ISSN: | 1664-8021 |
| DOI: | 10.3389/fgene.2021.730696 |
| Popis: | In response to DNA double-strand breaks (DSBs), chromatin modifications orchestrate DNA repair pathways thus safeguarding genome integrity. Recent studies have uncovered a key role for heterochromatin marks and associated factors in shaping DSB repair within the nucleus. In this review, we present our current knowledge of the interplay between heterochromatin marks and DSB repair. We discuss the impact of heterochromatin features, either pre-existing in heterochromatin domains or de novo established in euchromatin, on DSB repair pathway choice. We emphasize how heterochromatin decompaction and mobility further support DSB repair, focusing on recent mechanistic insights into these processes. Finally, we speculate about potential molecular players involved in the maintenance or the erasure of heterochromatin marks following DSB repair, and their implications for restoring epigenome function and integrity. |
| Databáze: | OpenAIRE |
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