Circulatory dynamics during surface-induced hypothermia under halothane-ether azeotrope anesthesia
| Autor: | David H. Dillard, Murray P. Sands, Robert Thomas, Eugene A. Hessel, Scot H. Merrick, K Haneda |
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| Rok vydání: | 1982 |
| Předmět: |
Pulmonary and Respiratory Medicine
Male Cardiac output Mean arterial pressure Hemodynamics Ether Dogs Hypothermia Induced medicine Animals business.industry Stroke volume Hypothermia Carbon Dioxide Oxygen Ethyl Ethers medicine.anatomical_structure Anesthesia Circulatory system Vascular resistance Heart Arrest Induced Surgery Female medicine.symptom Halothane Cardiology and Cardiovascular Medicine business Anesthesia Inhalation medicine.drug |
| Zdroj: | The Annals of thoracic surgery. 33(3) |
| ISSN: | 0003-4975 |
| Popis: | Circulatory dynamics during surface-induced deep hypothermia using the halothanediethyl ether azeotrope in 100% oxygen (O 2 ) without circulatory arrest and in 95% O 2 and 5% carbon dioxide (CO 2 ) with and without 60 minutes of arrest were evaluated in 15 adult mongrel dogs. Mean arterial pressure was lower in animals given 5% CO 2 than in animals given 100% O 2 during cooling. Cardiac output in the 5% CO 2 groups increased until 30°C cooling and then gradually decreased to 29% of control at 20°C. Cardiac output in the 100% O 2 group progressively decreased to 16% of control at 20°C cooling and was 51 to 77% of the output in the 5% CO 2 animals at comparable temperatures throughout the hypothermia procedure. The differences in cardiac output were attributed primarily to changes in stroke volume since heart rates were not significantly different. These changes were probably secondary to differences in systemic vascular resistance, which had increased sixfold in the animals given 100% O 2 and had only doubled in the 5% CO 2 groups at 20°C during cooling. Hemodynamic variables in animals given 5% CO 2 did not reveal significant differences in arrested versus nonarrested animals during early rewarming. However, with further warming, cardiac output, stroke volume, left ventricular stroke work, and mean pulmonary arterial and pulmonary artery wedge pressures were lower, and systemic and pulmonary vascular resistances were higher in the arrest group. We conclude that the improved results with halothane–diethyl ether azeotrope in 95% O 2 and 5% CO 2 during surface hypothermia are due to a greater cardiac output and reduced peripheral vascular resistance. |
| Databáze: | OpenAIRE |
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