Parathyroid hormone decreases in vivo insulin effect on glucose utilization
| Autor: | A. W. Saxe, R. L. Gingerich, Glenn Gibson, J. Levy |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Parathyroidectomy
Blood Glucose Male medicine.medical_specialty Time Factors Endocrinology Diabetes and Metabolism medicine.medical_treatment Parathyroid hormone Carbohydrate metabolism Impaired glucose tolerance Rats Sprague-Dawley Insulin Antagonists Endocrinology Internal medicine medicine Animals Insulin Orthopedics and Sports Medicine Infusions Parenteral Infusions Intravenous Hyperparathyroidism Carbohydrate homeostasis Chemistry medicine.disease Rats Kinetics Basal (medicine) Parathyroid Hormone Regression Analysis Calcium |
| Zdroj: | Calcified tissue international. 57(2) |
| ISSN: | 0171-967X |
| Popis: | Hyperparathyroidism is associated with impaired glucose tolerance, and parathyroidectomy may improve carbohydrate homeostasis. It has been suggested that parathyroid hormone (PTH) suppresses insulin secretion but it is unclear whether it also interferes with the peripheral action of insulin. To evaluate in vivo effects of PTH on insulinmediated glucose utilization, 15 male Sprague Dawley rats were continuously infused with rat PTH (1–34) using an Alzet miniosmotic pump at a rate of 0.03 nm/hour. Controls were infused with the vehicle alone. Following 5 days of PTH infusion, plasma calcium (Ca) levels were higher in the PTH-infused rats (12.3±0.2 versus 9.9±0.1 mg/dl, P |
| Databáze: | OpenAIRE |
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