Photodynamic diagnosis of non-muscle-invasive bladder cancer with hexaminolevulinate cystoscopy: a meta-analysis of detection and recurrence based on raw data
| Autor: | Eleanor R. Ray, Octavian Dragoescu, Juan Pablo Burgués, Michael J. Droller, Gregers G. Hermann, Alexander Karl, Dieter Jocham, Arnulf Stenzl, Joerg Schmidbauer, H. Barton Grossman, Patrice Jichlinski, J. Alfred Witjes, Yves Fradet, Maximilian Burger |
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| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Time Factors Urology Urinary Bladder Aetiology screening and detection [ONCOL 5] Kaplan-Meier Estimate Quality of Care [ONCOL 4] Molecular epidemiology [NCEBP 1] Translational research [ONCOL 3] Predictive Value of Tests Risk Factors medicine Humans Neoplasm Invasiveness Prospective cohort study Neoplasm Staging Intention-to-treat analysis Bladder cancer medicine.diagnostic_test business.industry Carcinoma in situ Aminolevulinic Acid Cystoscopy medicine.disease Confidence interval Surgery Treatment Outcome Urinary Bladder Neoplasms Relative risk Meta-analysis Neoplasm Recurrence Local business Carcinoma in Situ |
| Zdroj: | European Urology, 64, 846-54 European Urology, 64, 5, pp. 846-54 |
| ISSN: | 0302-2838 |
| Popis: | Item does not contain fulltext BACKGROUND: Studies on hexaminolevulinate (HAL) cystoscopy report improved detection of bladder tumours. However, recent meta-analyses report conflicting effects on recurrence. OBJECTIVE: To assess available clinical data for blue light (BL) HAL cystoscopy on the detection of Ta/T1 and carcinoma in situ (CIS) tumours, and on tumour recurrence. DESIGN, SETTING, AND PARTICIPANTS: This meta-analysis reviewed raw data from prospective studies on 1345 patients with known or suspected non-muscle-invasive bladder cancer (NMIBC). INTERVENTION: A single application of HAL cystoscopy was used as an adjunct to white light (WL) cystoscopy. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: We studied the detection of NMIBC (intention to treat [ITT]: n=831; six studies) and recurrence (per protocol: n=634; three studies) up to 1 yr. DerSimonian and Laird's random-effects model was used to obtain pooled relative risks (RRs) and associated 95% confidence intervals (CIs) for outcomes for detection. RESULTS AND LIMITATIONS: BL cystoscopy detected significantly more Ta tumours (14.7%; p |
| Databáze: | OpenAIRE |
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