Concomitant Induction of Apoptosis and Autophagy by Prostate Apoptosis Response-4 in Hypopharyngeal Carcinoma Cells
| Autor: | Yih-Chih Hsu, Chung-Hsing Chang, Lee-Ping Hsu, Peir-Rong Chen, Jeng-Woei Lee, Ling-Jung Wang, Wen-Lin Hsu, Dai-Wei Liu |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Oncology
medicine.medical_specialty Programmed cell death Cell Survival PAWR Apoptosis Biology Pathology and Forensic Medicine Hypopharyngeal Carcinoma Prostate Cell Line Tumor Internal medicine Sequestosome-1 Protein Autophagy medicine Humans Phosphorylation Adaptor Proteins Signal Transducing Hypopharyngeal Neoplasms Chemoradiotherapy Survival Analysis medicine.anatomical_structure Cell culture Apoptosis Regulatory Proteins |
| Zdroj: | The American Journal of Pathology. 184:418-430 |
| ISSN: | 0002-9440 |
| DOI: | 10.1016/j.ajpath.2013.10.012 |
| Popis: | The tumor-suppressive activity of prostate apoptosis response-4 (Par-4) has been demonstrated in a variety of human cancers. In this study, for the first time to our knowledge, we demonstrated that a higher intensity of Par-4 was significantly correlated with a better response in patients with hypopharyngeal carcinoma undergoing radiotherapy alone or concurrent chemoradiotherapy. Mechanistically, an elevated expression of Par-4 induced apoptosis of hypopharyngeal carcinoma cells and sensitized cells toward chemotherapeutic agents or X-ray irradiation. Along with apoptotic incitation, intriguingly, autophagic flux also increased on Par-4 stimulation and contributed to cell death. Moreover, the expressions of multiple common regulators involved in apoptosis and autophagy were regulated by Par-4. Taken together, our results suggested a prognostic role of Par-4 in hypopharyngeal carcinoma and showed novel activity of Par-4 in apoptosis and autophagy induction. |
| Databáze: | OpenAIRE |
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