High Serum Levels of Malondialdehyde and 8-OHdG are both Associated with Early Cognitive Impairment in Patients with Acute Ischaemic Stroke
| Autor: | Yuntao Liu, Jincai He, Huijun Chen, Zhihua Liu, Huihua Qiu, Xinjie Tu, Huiping Shen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Time Factors lcsh:Medicine medicine.disease_cause Logistic regression Gastroenterology Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Malondialdehyde Ischaemic stroke Medicine Humans Cognitive Dysfunction lcsh:Science Cognitive impairment Stroke Aged Multidisciplinary Receiver operating characteristic business.industry lcsh:R High serum Deoxyguanosine Middle Aged medicine.disease Surgery 030104 developmental biology chemistry ROC Curve 8-Hydroxy-2'-Deoxyguanosine lcsh:Q Female business 030217 neurology & neurosurgery Oxidative stress Biomarkers |
| Zdroj: | Scientific Reports Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017) |
| ISSN: | 2045-2322 |
| Popis: | Post-stroke cognitive impairment (PSCI) is an increasingly prevalent sequel after stroke that may associate with poor functional outcome and increased risk of recurrent stroke. We aimed to explore the relationship between oxidative stress biomarkers and the presence of PSCI. 193 first-ever acute ischaemic stroke patients were consecutively enrolled in the current study. The oxidative stress biomarkers malondialdehyde (MDA) and 8-hydroxydeoxyquanosine (8-OHdG) were measured within 24 h after admission. Cognition function was evaluated by the Mini-Mental State Examination (MMSE) at 1 month after stroke. Serum levels of 8-OHdG and MDA were both significantly higher in the PSCI (p |
| Databáze: | OpenAIRE |
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