Plasminogen activator inhibitors (PAI-1 and PAI-2) in normal pregnancies, pre-eclampsia and hydatidiform mole
| Autor: | A. Reith, D. J. Cruickshank, Bruce Bennett, Nuala A. Booth, N R Moore |
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| Rok vydání: | 1993 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Enzyme-Linked Immunosorbent Assay Preeclampsia Andrology Antigen Pre-Eclampsia Pregnancy Internal medicine Placenta Mole Fibrinolysis Plasminogen Activator Inhibitor 1 medicine Plasminogen Activator Inhibitor 2 Humans Zymography Prospective Studies Prospective cohort study reproductive and urinary physiology Eclampsia business.industry Plasminogen Activator Inhibitors Obstetrics and Gynecology General Medicine Hydatidiform Mole medicine.disease female genital diseases and pregnancy complications Endocrinology medicine.anatomical_structure Uterine Neoplasms Female business Plasminogen activator Maternal Age |
| Zdroj: | British journal of obstetrics and gynaecology. 100(4) |
| ISSN: | 0306-5456 |
| Popis: | Objective To examine the behaviour of the major inhibitors of fibrinolysis (PAI-1 and PAI-2) in normal pregnancy and pregnancy complicated by either pre-eclampsia or hydatidiform mole. Design Prospective study. Setting Antenatal Clinic and Maternity Hospital. Subjects Eleven women with established pre-eclampsia and eleven women, matched by age, parity, and duration of pregnancy who were undergoing uncomplicated pregnancy. Two women having surgery for hydatidiform mole. Main outcome measure Plasma levels of PAI-1 and PAI-2 antigens determined by sensitive specific ELISA. Functional identification of PAI-2 by nondenaturing gel electrophoresis with overlay zymography. Results In pre-eclampsia PAI-2 antigen was significantly lower than in normal pregnancy (105.3 ± 34.9 versues 187.1 ± 67.9 ng/ml; P |
| Databáze: | OpenAIRE |
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