As compared to allopurinol, urate-lowering therapy with febuxostat has superior effects on oxidative stress and pulse wave velocity in patients with severe chronic tophaceous gout
| Autor: | Mathias Forkmann, Anne-Kathrin Tausche, Martin Aringer, Carsten Wunderlich, C. Bielitz, S. Kopprasch, U. Richter, Marian Christoph |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Xanthine Oxidase Time Factors Gout Allopurinol Immunology Urology Renal function Pulse Wave Analysis Kidney Severity of Illness Index Gout Suppressants chemistry.chemical_compound Febuxostat Vascular Stiffness Rheumatology Germany medicine Immunology and Allergy Humans Hyperuricemia Prospective Studies Enzyme Inhibitors Xanthine oxidase Pulse wave velocity Aged business.industry Middle Aged medicine.disease Surgery Uric Acid Oxidative Stress Thiazoles Treatment Outcome chemistry Chronic Disease Uric acid Inflammation Mediators business Biomarkers medicine.drug Glomerular Filtration Rate |
| Zdroj: | Rheumatology international. 34(1) |
| ISSN: | 1437-160X |
| Popis: | We prospectively evaluated whether an effective 12-month uric acid-lowering therapy (ULT) with the available xanthine oxidase (XO) inhibitors allopurinol and febuxostat in patients with chronic tophaceous gout has an impact on oxidative stress and/or vascular function. Patients with chronic tophaceous gout who did not receive active ULT were included. After clinical evaluation, serum uric acid levels (SUA) and markers of oxidative stress were measured, and carotid–femoral pulse wave velocity (cfPWV) was assessed. Patients were then treated with allopurinol (n = 9) or with febuxostat (n = 8) to target a SUA level ≤360 μmol/L. After 1 year treatment, the SUA levels, markers of oxidative stress and the cfPWV were measured again. Baseline characteristics of both groups showed no significant differences except a higher prevalence of moderate impairment of renal function (estimated glomerular filtration rate |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink