Centromedian Nucleus and Epilepsy
| Autor: | Pablo Eduardo Saucedo-Alvarado, Ana Luisa Velasco, Francisco Díez de Velasco, Azari Reichrath, Gustavo Aguado-Carrillo, Haydeé Valdés-Quiroz |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Deep brain stimulation
Physiology medicine.medical_treatment Deep Brain Stimulation Stimulation Epilepsy Parvocellular cell Seizures Physiology (medical) Basal ganglia medicine Humans Cerebral Cortex Intralaminar Nucleus business.industry Intralaminar Thalamic Nuclei medicine.disease Electrodes Implanted medicine.anatomical_structure Neurology Cerebral cortex Centromedian nucleus Neurology (clinical) business Neuroscience |
| Zdroj: | Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society. 38(6) |
| ISSN: | 1537-1603 |
| Popis: | SUMMARY Centromedian thalamic nucleus is an intralaminar nucleus with vast connectivity to cerebral cortex and basal ganglia. It receives afferents from the brain stem through the central tegmental tract and is part of the diffuse thalamic projection system. Because the reticulothalamic system has been related to initiation and propagation of epileptic activity (centroencephalic theory of epilepsy), deep brain stimulation has been proposed to interfere with seizure genesis or propagation. Centromedian thalamic nucleus is a large nucleus laying nearby the anatomical references for stereotaxis and therefore a convenient surgical target to approach. Electrodes are implanted in the anterior ventral lateral part of the nucleus (parvocellular area), guided by intraoperative recruiting responses elicited by unilateral 6 to 8 Hz electrical stimulation delivered through the deep brain stimulation electrode. Therapeutic stimulation is delivered with the following parameters: 60 Hz, 450 μs, 3.0 V. Seizure control runs between 69% and 83% in different reports, decreasing mainly generalized seizures from the start, with significant improvement in neuropsychological performance. Significant decrease in seizure occurs from hours to days after the onset of deep brain stimulation. Some reports refer that seizure improvement may occur by the simple insertion of the deep brain stimulation electrodes, and therefore, it was used to treat refractory epileptic status. |
| Databáze: | OpenAIRE |
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