Comparative Analysis of Pediatric COVID-19 Infection in Southeast Asia, South Asia, Japan, and China
| Autor: | Quratulain Maha, Chin Seng Gan, Judith Ju-Ming Wong, Muralidharan Jayashree, Luming Shi, Hongxing Dang, Koh Cheng Thoon, Pei Chuen Lee, Jan Hau Lee, Kah Min Pon, Ririe Fachrina Malisie, Tomohiro Katsuta, Chee Fu Yung, Naoki Shimizu, Swee Fong Tang, Feng Xu, Qalab Abbas, Rehena Sultana, Soo Lin Chuah |
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| Přispěvatelé: | Lee Kong Chian School of Medicine (LKCMedicine), KK Women’s and Children’s Hospital |
| Rok vydání: | 2021 |
| Předmět: |
Male
China medicine.medical_specialty Asia Fever Coronavirus disease 2019 (COVID-19) MEDLINE Comorbidity Disease Logistic regression Severity of Illness Index Asymptomatic Article Risk Factors Virology Epidemiology medicine Humans Medicine [Science] Child Children Asia Southeastern business.industry COVID-19 Hospitals Infectious Diseases Cough Child Preschool Female Parasitology Observational study medicine.symptom business Demography |
| Zdroj: | The American Journal of Tropical Medicine and Hygiene |
| ISSN: | 1476-1645 0002-9637 |
| DOI: | 10.4269/ajtmh.21-0299 |
| Popis: | There is a scarcity of data regarding coronavirus disease 2019 (COVID-19) infection in children from southeast and south Asia. This study aims to identify risk factors for severe COVID-19 disease among children in the region. This is an observational study of children with COVID-19 infection in hospitals contributing data to the Pediatric Acute and Critical Care COVID-19 Registry of Asia. Laboratory-confirmed COVID-19 cases were included in this registry. The primary outcome was severity of COVID-19 infection as defined by the World Health Organization (WHO) (mild, moderate, severe, or critical). Epidemiology, clinical and laboratory features, and outcomes of children with COVID-19 are described. Univariate and multivariable logistic regression models were used to identify risk factors for severe/critical disease. A total of 260 COVID-19 cases from eight hospitals across seven countries (China, Japan, Singapore, Malaysia, Indonesia, India, and Pakistan) were included. The common clinical manifestations were similar across countries: fever (64%), cough (39%), and coryza (23%). Approximately 40% of children were asymptomatic, and overall mortality was 2.3%, with all deaths reported from India and Pakistan. Using the multivariable model, the infant age group, presence of comorbidities, and cough on presentation were associated with severe/critical COVID-19. This epidemiological study of pediatric COVID-19 infection demonstrated similar clinical presentations of COVID-19 in children across Asia. Risk factors for severe disease in children were age younger than 12 months, presence of comorbidities, and cough at presentation. Further studies are needed to determine whether differences in mortality are the result of genetic factors, cultural practices, or environmental exposures. Published version This study was funded by the SingHealth Duke- NUS Global Health Institute Pilot Research Grant (project no. Duke- NUS/SDGHI_RGA[Khoo]/2020/0006; principle investigator, J. J. M. W.). The Singapore Clinical Research Institute supported this study in kind by providing database development and maintenance services. C. F. Y. is supported by the SingHealth Duke-NUS Academic Medicine COVID-19 Rapid Response Research Grant AM/COV001/ 2020 (SRDUKAMC2001). |
| Databáze: | OpenAIRE |
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