Does Dexmedetomidine as a Neuraxial Adjuvant Facilitate Better Anesthesia and Analgesia? A Systematic Review and Meta-Analysis
Autor: | Jun-Jie Jin, Ke-Cheng Zhou, Guo-Zhong Chen, Wen Wang, Yu Chen, Hongtao Wang, Guang-Bin Cui, Yu-Lin Dong, Huang-Hui Wu |
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Rok vydání: | 2014 |
Předmět: |
Comparative Effectiveness Research
medicine.medical_treatment General Anesthesia lcsh:Medicine Neuraxial blockade law.invention Randomized controlled trial Anesthesiology law Medicine and Health Sciences polycyclic compounds Quality of Care Anesthesia Drug Interactions Anesthetics Local lcsh:Science Randomized Controlled Trials as Topic Anesthesiology Monitoring Pain Postoperative Multidisciplinary Clinical Pharmacology Analgesics Non-Narcotic Chemotherapy Adjuvant Research Design Meta-analysis Physical Sciences Hypotension medicine.symptom Adjuvant Dexmedetomidine Statistics (Mathematics) hormones hormone substitutes and hormone antagonists Research Article medicine.drug endocrine system Drug Research and Development Clinical Research Design Sedation Surgical and Invasive Medical Procedures Anesthetic Mechanisms Research and Analysis Methods Bradycardia medicine Humans Pain Management Statistical Methods Adverse effect Pharmacology Health Care Policy business.industry lcsh:R Health Care Pharmacodynamics lcsh:Q Local and Regional Anesthesia Analgesia Clinical Medicine business Adjuvant Analgesic Mathematics Meta-Analysis |
Zdroj: | PLoS ONE, Vol 9, Iss 3, p e93114 (2014) PLoS ONE |
ISSN: | 1932-6203 |
DOI: | 10.1371/journal.pone.0093114 |
Popis: | BACKGROUND: Neuraxial application of dexmedetomidine (DEX) as adjuvant analgesic has been invetigated in some randomized controlled trials (RCTs) but not been approved because of the inconsistency of efficacy and safety in these RCTs. We performed this meta-analysis to access the efficacy and safety of neuraxial DEX as local anaesthetic (LA) adjuvant. METHODS: We searched PubMed, PsycINFO, Scopus, EMBASE, and CENTRAL databases from inception to June 2013 for RCTs that investigated the analgesia efficacy and safety for neuraxial application DEX as LA adjuvant. Effects were summarized using standardized mean differences (SMDs), weighed mean differences (WMDs) or odds ratio (OR) with suitable effect model. The primary outcomes were postoperative pain intensity and analgesic duration, bradycardia and hypotension. RESULTS: Sixteen RCTs involving 1092 participants were included. Neuraxial DEX significantly decreased postoperative pain intensity (SMD, -1.29; 95% confidence interval (CI), -1.70 to -0.89; P |
Databáze: | OpenAIRE |
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