Does Dexmedetomidine as a Neuraxial Adjuvant Facilitate Better Anesthesia and Analgesia? A Systematic Review and Meta-Analysis

Autor: Jun-Jie Jin, Ke-Cheng Zhou, Guo-Zhong Chen, Wen Wang, Yu Chen, Hongtao Wang, Guang-Bin Cui, Yu-Lin Dong, Huang-Hui Wu
Rok vydání: 2014
Předmět:
Comparative Effectiveness Research
medicine.medical_treatment
General Anesthesia
lcsh:Medicine
Neuraxial blockade
law.invention
Randomized controlled trial
Anesthesiology
law
Medicine and Health Sciences
polycyclic compounds
Quality of Care
Anesthesia
Drug Interactions
Anesthetics
Local

lcsh:Science
Randomized Controlled Trials as Topic
Anesthesiology Monitoring
Pain
Postoperative

Multidisciplinary
Clinical Pharmacology
Analgesics
Non-Narcotic

Chemotherapy
Adjuvant

Research Design
Meta-analysis
Physical Sciences
Hypotension
medicine.symptom
Adjuvant
Dexmedetomidine
Statistics (Mathematics)
hormones
hormone substitutes
and hormone antagonists

Research Article
medicine.drug
endocrine system
Drug Research and Development
Clinical Research Design
Sedation
Surgical and Invasive Medical Procedures
Anesthetic Mechanisms
Research and Analysis Methods
Bradycardia
medicine
Humans
Pain Management
Statistical Methods
Adverse effect
Pharmacology
Health Care Policy
business.industry
lcsh:R
Health Care
Pharmacodynamics
lcsh:Q
Local and Regional Anesthesia
Analgesia
Clinical Medicine
business
Adjuvant Analgesic
Mathematics
Meta-Analysis
Zdroj: PLoS ONE, Vol 9, Iss 3, p e93114 (2014)
PLoS ONE
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0093114
Popis: BACKGROUND: Neuraxial application of dexmedetomidine (DEX) as adjuvant analgesic has been invetigated in some randomized controlled trials (RCTs) but not been approved because of the inconsistency of efficacy and safety in these RCTs. We performed this meta-analysis to access the efficacy and safety of neuraxial DEX as local anaesthetic (LA) adjuvant. METHODS: We searched PubMed, PsycINFO, Scopus, EMBASE, and CENTRAL databases from inception to June 2013 for RCTs that investigated the analgesia efficacy and safety for neuraxial application DEX as LA adjuvant. Effects were summarized using standardized mean differences (SMDs), weighed mean differences (WMDs) or odds ratio (OR) with suitable effect model. The primary outcomes were postoperative pain intensity and analgesic duration, bradycardia and hypotension. RESULTS: Sixteen RCTs involving 1092 participants were included. Neuraxial DEX significantly decreased postoperative pain intensity (SMD, -1.29; 95% confidence interval (CI), -1.70 to -0.89; P
Databáze: OpenAIRE