Characterization of red-capped mangabey tetherin: implication for the co-evolution of primates and their lentiviruses
| Autor: | Fengrong Ren, Junko S. Takeuchi, Rokusuke Yoshikawa, Hiroshi Tanaka, Yusuke Nakano, Yoshio Koyanagi, Kei Sato, Kenta Matsuda, Tomoko Kobayashi, Vanessa M. Hirsch, Eri Yamada, Naoko Misawa, Yuichi Kimura |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Primates
viruses Molecular Sequence Data Simian medicine.disease_cause GPI-Linked Proteins Article Evolution Molecular Viral Proteins Retrovirus medicine Animals Mangabey Amino Acid Sequence Cercocebus torquatus Genetics Multidisciplinary biology Phylogenetic tree Base Sequence virus diseases Simian immunodeficiency virus biology.organism_classification Virology Biological Evolution Viral evolution Tetherin Simian Immunodeficiency Virus |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | Primate lentiviruses including human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency viruses (SIVs) evolved through the acquisition of antagonists against intrinsic host restriction factors, such as tetherin. It is widely accepted that HIV-1 has emerged by zoonotic transmission of SIV in chimpanzee (SIVcpz), and that SIVcpz Nef protein antagonizes chimpanzee tetherin. Although Nef of SIVcpz shares a common ancestor with that of SIVrcm, an SIV in red-capped mangabey (Cercocebus torquatus), it remains unclear whether SIVrcm Nef can antagonize tetherin of its natural host. In this study, we determine the sequence of red-capped mangabey tetherin for the first time and directly demonstrate that SIVrcm Nef is the bona fide antagonist of red-capped mangabey tetherin. These findings suggest that SIVrcm Nef is the functional ancestor of SIVcpz Nef. Moreover, molecular phylogenetic analyses reveal that tetherins of the genus Cercocebus have experienced adaptive evolution, which is presumably promoted by primate lentiviruses. |
| Databáze: | OpenAIRE |
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