Prognostic value of the 21-gene recurrence score for regional recurrence in patients with estrogen receptor-positive breast cancer
| Autor: | Sung-Bae Kim, Jong Won Lee, Il Yong Chung, Jae Ho Jeong, Minji Koh, Jinhong Jung, Eun Kyung Choi, Seung Do Ahn, Su Ssan Kim |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Cancer Research medicine.medical_specialty medicine.drug_class medicine.medical_treatment Estrogen receptor Breast Neoplasms Gastroenterology 03 medical and health sciences 0302 clinical medicine Breast cancer Internal medicine medicine Biomarkers Tumor Humans In patient Risk factor Mastectomy Neoplasm Staging medicine.diagnostic_test business.industry Medical record medicine.disease Prognosis 030104 developmental biology Oncology Receptors Estrogen Estrogen 030220 oncology & carcinogenesis Female Neoplasm Recurrence Local Oncotype DX business |
| Zdroj: | Breast cancer research and treatment. 188(3) |
| ISSN: | 1573-7217 |
| Popis: | To evaluate the prognostic value of the 21-gene recurrence score (RS) for regional recurrence (RR) in patients with estrogen receptor-positive breast cancer. We reviewed the medical records of 446 patients who underwent 21-gene RS assay after breast-conserving surgery or mastectomy. The high-RS group was defined as patients who were (1) older than 50 years with an RS of 26 or higher, or (2) 50 years or younger with an RS of 16 or higher. The 5-year rates of local recurrence (LR), RR, and distant metastasis (DM) were 2.2%, 2.7%, and 4.7%, respectively. The 5-year overall survival (OS) rate was 99.1%. Of the patients, 269 (60.3%) had low-RS, while 177 (39.7%) had high-RS. The 5-year OS rate of the high-RS group was significantly lower than that of the low-RS. The 5-year rates of RR and DM in the high-RS group were significantly higher than those in the low-RS group, while the LR rates did not differ significantly. In multivariable analysis, the high-RS group had a significant relationship with increased RR rate (p = 0.037). Patients who had both high-RS and clinical high-risk features had a significantly higher 5-year RR rate (7.9%) compared with other groups. High-RS was an independent risk factor for RR. The significantly higher RR rate of patients with both high-RS and clinical high-risk features compared with other groups suggests that this patient group can be a potential candidate for regional nodal irradiation. |
| Databáze: | OpenAIRE |
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