Reference Ranges of Different Lymphocyte Subsets in Indian Children: A Multi-Centric Study
| Autor: | Vandana Saxena, Anita Desai, Ranjana Y Minz, Nalini Janakiram, Surjit Singh, Shilpa Bembalkar, Madhuri Thakar, A. Mukherjee, Manisha Madkaikar, Arun Kumar Singh, Mitali Chatterjee, Vydianathan Ravi, Niranjan Shivanna, Vasantha Mahesh |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adolescent
CD3 Antigens CD19 Neonatal age CD19 Flow cytometry 03 medical and health sciences 0302 clinical medicine Immune system Reference Values 030225 pediatrics Humans Medicine Lymphocyte Count 030212 general & internal medicine Child Whole blood biology medicine.diagnostic_test business.industry Infant Newborn Infant Flow Cytometry Lymphocyte Subsets Cross-Sectional Studies Child Preschool Pediatrics Perinatology and Child Health Immunology biology.protein business CD8 Lymphocyte subsets |
| Zdroj: | Indian Pediatrics. 58:424-429 |
| ISSN: | 0974-7559 0019-6061 |
| Popis: | To determine the reference ranges of various lymphocyte subsets in healthy Indian children. Descriptive cross-sectional study. Four centers in India representing four geographical regions. 1104 children from neonatal age to 18 years of age. One time measurement of absolute count and percentages of different lymphocyte subsets i.e. T lymphocytes (CD3+T, CD4+T, CD8+T cells), B lymphocytes (CD19+B cells) and Natural Killer lymphocytes (CD15/16+NK cells) in whole blood using multicolor flow cytometry. The absolute cell counts of various lymphocytes were found to increase from newborn to 10 months of age, followed by gradual decline until 18 years; however, the proportion of immune cells remained largely similar. Gender did not have a significant impact on the reference ranges, whereas counts were found to vary as per the geographical locations. These reference ranges will be useful to monitor and predict the immune status in pediatric population. The variation in region wise ranges could be confirmed by testing more number of samples in the specific age groups. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink