Influence of Periodontal Disease on cardiovascular markers in Diabetes Mellitus patients

Autor: Maiara Arrruda Schulz, Maria Aparecida Neves Jardini, Magnus Gidlund, André Luiz Sehnem, Juliana de Fátima Pedroso, Ghadeer Albattarni, Andrea Moreira Monteiro, Zahra Lotfollahi, Antônio Martins Figueiredo Neto
Přispěvatelé: Universidade Estadual Paulista (Unesp), Universidade de São Paulo (USP), Technique manageress
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Blood Glucose
lcsh:Medicine
01 natural sciences
Gastroenterology
Gingivitis
0302 clinical medicine
lcsh:Science
Multidisciplinary
Diabetes
Dental Plaque Index
Lipoproteins
LDL
Cholesterol
Cardiovascular Diseases
lipids (amino acids
peptides
and proteins)
medicine.symptom
Periodontal Index
medicine.medical_specialty
Periodontal Debridement
Lipoproteins
Bleeding on probing
Dental diseases
Article
010309 optics
03 medical and health sciences
Periodontal disease
Internal medicine
Diabetes mellitus
0103 physical sciences
Periodontal Attachment Loss
medicine
Humans
Clinical significance
Periodontitis
IMUNOLOGIA
Triglycerides
Glycemic
Glycated Hemoglobin
Inflammation
business.industry
lcsh:R
030206 dentistry
medicine.disease
Oxidative Stress
Diabetes Mellitus
Type 2
Dental Scaling
lcsh:Q
business
Biomarkers
Zdroj: Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports
Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
ISSN: 2045-2322
DOI: 10.1038/s41598-019-52498-7
Popis: Made available in DSpace on 2020-12-12T02:23:36Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-12-01 The objective of the present study was to establish if individuals with Diabetes Mellitus (DM2) and periodontal diseases (gingivitis or periodontitis) presented an increase in the concentration of modified LDL (moLDL) and what is the influence of periodontal treatment on the decrease of moLDL particles with consequent improvement in the parameters of DM2. Twenty-four diabetic patients with periodontitis (Group 1) and twenty-four diabetic patients with gingivitis (Group 2) were followed up for a period of 12 months. Group 1 was treated with periodontal debridement, and Group 2 received supra-gingival scaling and prophylaxis. In both groups, periodontal clinical parameters: probing depth (PD), clinical attachment level (CAL), gingival resection (GR), bleeding on probing index (BOP) and plaque index; inflammatory serum markers (glycemia, A1c, total cholesterol, HDL-cholesterol (HDL-c), LDL-cholesterol (LDL-c), triglycerides and hs-CRP) and oxidized LDL (oxLDL) were measured at baseline, t = 6 and t = 12 months after treatment. Solutions of LDL were analyzed using the nonlinear optical Z-Scan and optical absorption techniques. The periodontal clinical parameters showed significant improvement (p < 0.05) in both Group after 12 months. For both groups, total cholesterol, HDL-c, LDL-c, triglycerides and A1c levels did not show significant reductions after periodontal therapy. hs-CRP levels in Group 1 presented a significant reduction after 12 months. The glycemic rate and the oxLDL concentrations did not show significant differences as a function of time. The optical measurements of LDL solutions revealed an improvement of the LDL-c quality in both groups. Periodontal debridement was able to improve periodontal parameters and the quality of LDL-c in diabetic patients but without changes in the oxLDL concentration in both groups. Considering the clinical relevance, the reduction of infectious and inflammatory sites present in the oral cavity through periodontal therapy may help with the control and prevention of hyperglycemia and precursors of cardiovascular diseases. São Paulo State University (UNESP) School of Sciences and Technology Department of Diagnosis and Surgery University of São Paulo (USP) Institute of Physics Labvi Valle Technique manageress University of São Paulo Institute of Biomedical Science Department of Immunology São Paulo State University (UNESP) School of Sciences and Technology Department of Diagnosis and Surgery
Databáze: OpenAIRE
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