Alport syndrome diagnosed by immunofluorescence using a new monoclonal antibody
| Autor: | Shuei Nakayama, Hikaru Koide, Isao Shirato, Yasuhiko Tomino, Ikuo Kiyatake |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Collagen Type IV
Pathology medicine.medical_specialty Heterozygote Adolescent medicine.drug_class Kidney Glomerulus Fluorescent Antibody Technique Nephritis Hereditary urologic and male genital diseases Monoclonal antibody Immunofluorescence Autoantigens Basement Membrane Type IV collagen Internal Medicine medicine Humans Alport syndrome Microscopic hematuria Basement membrane medicine.diagnostic_test urogenital system business.industry Glomerular basement membrane Antibodies Monoclonal General Medicine medicine.disease female genital diseases and pregnancy complications Pedigree medicine.anatomical_structure Immunology Female Renal biopsy Collagen business |
| Zdroj: | Internal medicine (Tokyo, Japan). 32(1) |
| ISSN: | 0918-2918 |
| Popis: | A 14-year-old female with microscopic hematuria was admitted for a renal biopsy. She had a family history of renal disease without deafness. The findings of light microscopy and conventional immunofluorescence were normal. Electron microscopy showed a diffuse thinning of the glomerular basement membrane (GBM) with its mild splitting. Irregular thickening of GBM and glomerular small dense particles was not observed. Thin basement membrane syndrome was suspected from these findings. However, it was difficult to differentiate from Alport syndrome. Immunofluorescence analysis using the monoclonal antibody to the 28-kilodalton monomers of the noncollagenous domain of type IV collagen verified the diagnosis of heterozygous Alport syndrome. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|