Low-Dose Propranolol for Multiple Hepatic and Cutaneous Hemangiomas With Deranged Liver Function
| Autor: | Swee T. Tan, Tinte Itinteang, Philip Leadbitter |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Male
Mesoderm medicine.medical_specialty Angiotensin receptor Skin Neoplasms Adrenergic beta-Antagonists Propranolol Hemangioma Internal medicine medicine Humans Involution (medicine) Hemogenic endothelium Dose-Response Relationship Drug business.industry Liver Neoplasms Infant Newborn medicine.disease Phenotype medicine.anatomical_structure Endocrinology Liver Pediatrics Perinatology and Child Health Liver function business Follow-Up Studies medicine.drug |
| Zdroj: | Pediatrics. 127:e772-e776 |
| ISSN: | 1098-4275 0031-4005 |
| Popis: | We report here the case of an infant with multiple hepatic and cutaneous infantile hemangiomas (IHs) associated with deranged liver function who was treated successfully with low-dose propranolol. We also discuss our recent data that show that IH is a developmental anomaly of hemogenic endothelium derived from primitive mesoderm with a neural crest-cell phenotype. We previously presented evidence that this hemogenic endothelium is governed by the renin-angiotensin system, which we propose can account for both the action of propranolol and the process of spontaneous involution of IH. We further speculate on the possibility of using inhibitors of angiotensin-converting enzyme and that of angiotensin II receptor 2 as potential alternative therapies. |
| Databáze: | OpenAIRE |
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