Prospective multicenter randomized trial of fast ventricular tachycardia termination by prolonged versus conventional anti-tachyarrhythmia burst pacing in implantable cardioverter-defibrillator patients-Atp DeliVery for pAiNless ICD thErapy (ADVANCE-D) Trial results
| Autor: | Maurizio Lunati, Johann Mermi, Massimo Santini, Alessandro Proclemer, Xavier Navarro, Tiziana De Santo, Pascal Defaye, Giulio Molon, Axel Kloppe, Silvia del Castillo-Arroys, Elisabetta Santi |
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| Rok vydání: | 2009 |
| Předmět: |
Tachycardia
Male medicine.medical_specialty Ventricular Tachyarrhythmias medicine.medical_treatment Treatment outcome Electric Countershock Ventricular tachycardia Risk Assessment Article law.invention Randomized controlled trial law Risk Factors Internal medicine Physiology (medical) medicine Prevalence Humans Pacing cardiovascular diseases Prospective Studies Prospective cohort study business.industry Cardiac Pacing Artificial Shock Middle Aged Implantable cardioverter-defibrillator medicine.disease Icd therapy Survival Analysis Ventricular tachyarrhythmia Europe Survival Rate Treatment Outcome cardiovascular system Cardiology Tachycardia Ventricular Programming Female medicine.symptom Implantable business Cardiology and Cardiovascular Medicine Defibrillators |
| Zdroj: | Journal of Interventional Cardiac Electrophysiology |
| ISSN: | 1572-8595 |
| Popis: | Purpose The purpose of the trial was to quantify and compare the efficacy of two different sequences of burst anti-tachycardia pacing (ATP) strategies for the termination of fast ventricular tachycardia. Methods The trial was prospective, multicenter, parallel and randomized, enrolling patients with an indication for implantable cardioverter-defibrillator implantation. Results From February 2004, 925 patients were randomized and followed-up for 12 months. Eight pulses ATP terminated 64% of episodes vs. 70% in the 15-pulse group (p = 0.504). Fifteen pulses proved significantly better in patients without a previous history of heart failure (p = 0.014) and in patients with LVEF ≥ 40% (p = 0.016). No significant differences between groups were observed with regard to syncope/near-syncope occurrence. Conclusion In the general population, 15-pulse ATP is as effective and safe as eight-pulse ATP. The efficacy of ATP on fast ventricular arrhythmias confirmed once more the striking importance of careful device programming in order to reduce painful shocks. |
| Databáze: | OpenAIRE |
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