Determination of antimicrobial susceptibility patterns and inducible clindamycin resistance in Staphylococcus aureus strains recovered from southeastern Turkey
| Autor: | Efgan Dogan Gayyurhan, Tekin Karsligil, Fahriye Ekşi, Ayşen Bayram |
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| Rok vydání: | 2011 |
| Předmět: |
Transcriptional Activation
Microbiology (medical) Staphylococcus aureus Antibiotic susceptibility Turkey Inducible clindamycin resistance medicine.medical_treatment Dalfopristin Biology Staphylococcal infections medicine.disease_cause Microbiology chemistry.chemical_compound Disk Diffusion Antimicrobial Tests Immunology and Microbiology(all) Drug Resistance Bacterial Prevalence medicine Humans Immunology and Allergy General Immunology and Microbiology Teicoplanin Clindamycin Quinupristin General Medicine Staphylococcal Infections biochemical phenomena metabolism and nutrition bacterial infections and mycoses medicine.disease Anti-Bacterial Agents Infectious Diseases chemistry Linezolid Vancomycin medicine.drug |
| Zdroj: | Journal of Microbiology, Immunology and Infection. 44:57-62 |
| ISSN: | 1684-1182 |
| DOI: | 10.1016/j.jmii.2011.01.011 |
| Popis: | Background In this study, we determined the susceptibility patterns of Staphylococcus aureus strains to various antimicrobials and prevalence of inducible clindamycin resistance (ICR) in these isolates. Methods Two hundred and one S aureus strains, isolated from various clinical samples, were included in the study. Antibiotic susceptibilities were studied by disc diffusion method on the basis of the guidelines by the Clinical and Laboratory Standards Institute. The disc diffusion induction test (D test) was applied to determine ICR resistance among erythromycin-resistant S aureus isolates. Results Of the 201 S aureus strains, 101 (50.2%) were resistant to methicillin. All strains were susceptible to vancomycin, teicoplanin, quinupristin/dalfopristin, and linezolid. It was found that 54 (53.4%) methicillin-resistant S aureus (MRSA) strains were erythromycin resistant, and 40 (39.6%) of them showed constitutive clindamycin resistance. ICR was detected in seven (6.9%) MRSA strains. It was found that 13 (13.0%) methicillin-susceptible S aureus (MSSA) strains were erythromycin resistant. Constitutive clindamycin resistance was seen in one (1.0%) MSSA strain, and ICR was detected in 10 (10.0%) cases. Conclusion There was a high rate of methicillin resistance among S aureus strains in our hospital. However, no statistically significant difference of ICR was observed between MRSA and MSSA strains ( p =0.434) or between inpatients and outpatients ( p =0.804). It was concluded that ICR should be routinely evaluated in each S aureus case to avoid therapy failure among patients. |
| Databáze: | OpenAIRE |
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