809-3 Desipramine Attenuates the Cardiac Sympathetic Nerve Terminal Abnormalities in Congestive Heart Failure
| Autor: | Suzanne Y. Felten, Chang-seng Liang, Akito Yatani, Yoshihiro Himura, Michihiro Kashiki |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Tachycardia
medicine.medical_specialty Cardiac output Tyrosine hydroxylase business.industry medicine.disease Reuptake Norepinephrine (medication) Endocrinology Heart failure Desipramine Internal medicine Aortic pressure Cardiology cardiovascular system Medicine cardiovascular diseases medicine.symptom Cardiology and Cardiovascular Medicine business human activities medicine.drug |
| Zdroj: | Journal of the American College of Cardiology. (2):425A-426A |
| ISSN: | 0735-1097 |
| DOI: | 10.1016/0735-1097(95)93225-2 |
| Popis: | We have shown that cardiac norepinephrine (NE) reuptake activity and tyrosine hydroxylase (TH), a rate-limiting enzyme for NE synthesis, are reduced in congestive heart failure (CHF). To determine whether the changes of TH are caused by neurotoxic effects of NE, we administered the neuronal uptake inhibitor desipramine (DMI, 225 mg/day) to pacing-induced CHF and sham-operated (SHAM) dogs for 6 weeks. CHF was characterized by tachycardia, low aortic pressure, elevated left atrial pressure, decreased left ventricular dP/dt and reduced cardiac output. DMI produced no hemodynamic effects. The effects of OMI on left ventricular NE uptake activity (fmol/mg/15 min) and immunocytochemical TH profiles were: Group NE uptake TH SHAM (n = 12) 133 ± 9 813 ± 43 SHAM + OMI (n = 6) 49 ± 11* 769 ± 14 CHF (n = 12) 64 ± 8* 409 ± 42* CHF + OMI (n = 7) 40 ± 9*,† 642 ± 49*,† Values are mean ± SE * p |
| Databáze: | OpenAIRE |
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