Serum Cholesterol, Beta-Carotene, and Risk of Lung Cancer
| Autor: | Arthur H. Rossof, Christine C. Tangney, Richard B. Shekelle, Jeremiah Stamler |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Male medicine.medical_specialty Lung Neoplasms Epidemiology Population Physiology Cohort Studies chemistry.chemical_compound Risk Factors medicine Humans Lung cancer education Chicago education.field_of_study business.industry Cholesterol Smoking Middle Aged beta Carotene medicine.disease Carotenoids Confidence interval Diet chemistry Relative risk Cohort business Cohort study |
| Zdroj: | Epidemiology. 3:282-287 |
| ISSN: | 1044-3983 |
| Popis: | This paper hypothesizes that beta-carotene mediates the association between low serum cholesterol and increased risk of lung cancer, predicts that the association should be greater in population strata with low intake of beta-carotene than in those with high intake if the hypothesis is correct, and investigates this prediction with data from a 24-year cohort study of 1,960 middle-aged employed men. In the total cohort, serum cholesterol was not related to risk of lung cancer. The relative risk associated with a difference of −1.0 mmol per liter in serum cholesterol was 1.01 (95% confidence interval of 0.80–1.27) after adjustment for cigarette smoking, age, and intake of beta-carotene. In contrast, however, when the study group was restricted to men with intake of betacarotene |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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