Synthesis, biological evaluation of new oxazolidino-sulfonamides as potential antimicrobial agents
| Autor: | Rajesh V.C.R.N.C. Shetti, Ahmed Kamal, P. Swapna, Anver Basha Shaik, M. P. Narasimha Rao, Soma Gupta |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Antifungal Agents
Molecular Conformation Moderate activity Microbial Sensitivity Tests Gram-Positive Bacteria Structure-Activity Relationship chemistry.chemical_compound Gram-Negative Bacteria Drug Discovery Food science Candida albicans Oxazoles Biological evaluation Pharmacology Sulfonamides Dose-Response Relationship Drug biology Organic Chemistry Fungi General Medicine biology.organism_classification Antimicrobial Combinatorial chemistry Anti-Bacterial Agents chemistry Lipophilicity Linezolid Bacteria |
| Zdroj: | European Journal of Medicinal Chemistry. 62:661-669 |
| ISSN: | 0223-5234 |
| Popis: | A number of linezolid-like oxazolidino-sulfonamides (7a–y and 8a–b) were designed and synthesized with a view to develop antimicrobial agents with improved properties. Most of the synthesized compounds showed good to moderate activity against a panel of standard Gram-positive and Gram-negative bacteria and fungal strains. The compounds 7i and 7v exhibited significant activity, with a MIC value of 2.0–6.0 μg/mL against a panel of Gram-positive and Gram-negative bacteria. These compounds also showed activity against Candida albicans, with a MIC value of 4.0 μg/mL. A correlation of the antimicrobial activity with calculated lipophilicity values (C log P) is also presented. |
| Databáze: | OpenAIRE |
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