Idiopathic Pulmonary Fibrosis: Evaluation with Positron Emission Tomography
| Autor: | Horst-Helmut Meissner, S. Ali Khonsary, Charles V. Brown, Guy W. Soo Hoo, Silverio M. Santiago, M. Mandelkern |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine Pathology medicine.medical_specialty Biopsy Pulmonary Fibrosis Pathogenesis Idiopathic pulmonary fibrosis Fluorodeoxyglucose F18 Pulmonary fibrosis Humans Medicine Lung Idiopathic interstitial pneumonia Aged Aged 80 and over Carbon Monoxide medicine.diagnostic_test business.industry Total Lung Capacity Respiratory disease Interstitial lung disease Middle Aged medicine.disease Positron emission tomography Positron-Emission Tomography Pulmonary Diffusing Capacity Radiopharmaceuticals Tomography X-Ray Computed business |
| Zdroj: | Respiration. 73:197-202 |
| ISSN: | 1423-0356 0025-7931 |
| DOI: | 10.1159/000088062 |
| Popis: | Background: The pathogenesis of interstitial lung disease remains under investigation, but may be related to increased inflammatory or cellular activity. This activity may be detectable with physiologic imaging. Objectives: We investigated the role of physiologic imaging using 18F-2-fluoro-2-deoxy-D-glucose (18FDG)-positron emission tomography (PET) scans in idiopathic pulmonary fibrosis (IPF). Methods: Seven male patients with histologically confirmed IPF underwent 18FDG-PET scans. Scans were analyzed qualitatively and interpreted as positive or negative. Patients also underwent pulmonary function tests and computed tomography (CT) scans. Results: The average total lung capacity was 71 ± 22% predicted (mean ± SD) and diffusing capacity for carbon monoxide was 44 ± 14% predicted. All had changes consistent with IPF on chest CT and 2 patients had ground glass attenuation. Six of seven patients (86%) had a positive 18FDG-PET scan. Changes in the 18FDG-PET scan were seen in 1 patient corresponding to changes in clinical status. Conclusions: Our findings suggest that 18FDG-PET scans may be helpful in the evaluation of IPF. Increased activity suggests active disease and changes in response to therapy. |
| Databáze: | OpenAIRE |
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