EVALUATION OF A STROMA-FREE HEMOGLOBIN SOLUTION FOR USE AS A PLASMA EXPANDER
| Autor: | Harry Lopas, J. Raymond Helbert, S. Frederick Rabiner, Lila H. Friedman |
|---|---|
| Rok vydání: | 1967 |
| Předmět: |
medicine.medical_specialty
Immunology Plasma Substitutes Renal function Shock Hemorrhagic Kidney Article Methemoglobin Hemoglobins chemistry.chemical_compound Dogs Oxygen Consumption Internal medicine medicine Animals Urea Immunology and Allergy Aminohippuric acid Bloodletting Blood coagulation test Creatinine Chemistry Aminohippuric Acids Kidney metabolism Solutions Endocrinology medicine.anatomical_structure Biochemistry Prothrombin Time Blood Coagulation Tests Hemoglobin medicine.drug |
| Zdroj: | The Journal of Experimental Medicine |
| ISSN: | 1540-9538 0022-1007 |
| DOI: | 10.1084/jem.126.6.1127 |
| Popis: | The preparation of large quantities of a stable, stroma-free hemoglobin solution without coagulant activity is described. Following infusion of this solution into phlebotomized dogs, there is no methemoglobin formation, no adverse effects on vital signs, and no demonstrable activation of blood coagulation. The hemoglobin maintains its oxygen-carrying capacity and liberates oxygen into tissues. Acute and chronic effects on renal function following infusion of this preparation were also studied and no effect on clearance of urea, creatinine, or P.A.H. could be demonstrated. There was no change in urinary output and histological sections revealed no lesions attributable to hemoglobin toxicity. It is concluded that a stroma-free hemoglobin solution may have use as a plasma expander. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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