Genetic Factors Associated with COPD Depend on the Ancestral Caucasian/Amerindian Component in the Mexican Population
| Autor: | Ramcés Falfán-Valencia, Rafael Hernández-Zenteno, Alejandra Ramírez-Venegas, Gloria Pérez-Rubio, Fernando Flores-Trujillo, Irma Silva-Zolezzi, Juan Carlos Fernández-López |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
CYP2A6
CHRNA5 Clinical Biochemistry Single-nucleotide polymorphism macromolecular substances Lower risk Article Hispanic paradox 03 medical and health sciences 0302 clinical medicine Genetic predisposition Medicine COPD 030212 general & internal medicine Genetic variability Allele Genotyping Genetics lcsh:R5-920 business.industry musculoskeletal neural and ocular physiology Haplotype CHRNA3 medicine.disease respiratory tract diseases 030228 respiratory system nervous system Mexican mestizo lcsh:Medicine (General) business genetic susceptibility |
| Zdroj: | Diagnostics Volume 11 Issue 4 Diagnostics, Vol 11, Iss 599, p 599 (2021) |
| ISSN: | 2075-4418 |
| DOI: | 10.3390/diagnostics11040599 |
| Popis: | Genetic variability influences the susceptibility to and severity of complex diseases there is a lower risk of COPD in Hispanics than in non-Hispanic Caucasians. In this study, we included 830 Mexican-Mestizo subjects 299 were patients with COPD secondary to tobacco smoking, and 531 were smokers without COPD. We employed a customized genotyping array of single nucleotide polymorphisms (SNPs). The population structure was evaluated by principal component analysis and allele association through a logistic regression model and haplotype identification. In this study, 118 individuals were identified with a high Caucasian component and 712 with a high Amerindian component. Independent of the ancestral contribution, two SNPs were associated with a reduced risk (p ≤ 0.01) of developing COPD in the CYP2A6 (rs4105144) and CYP2B6 (rs10426235) genes however, a haplotype was associated with an increased risk of COPD (p = 0.007, OR = 2.47) in the CHRNA5-CHRNA3 loci among smokers with a high Caucasian component. In Mexican-Mestizo smokers, there are SNPs in genes that encode proteins responsible for the metabolism of nicotine associated with a lower risk of COPD individuals with a high Caucasian component harboring a haplotype in the CHRNA5-CHRNA3 loci have a higher risk of suffering from COPD. |
| Databáze: | OpenAIRE |
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