Cyclic Polymer Grafts That Lubricate and Protect Damaged Cartilage
Autor: | Emma Cavalli, Jan-Georg Rosenboom, Edmondo M. Benetti, Giulia Morgese, Marcy Zenobi-Wong |
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Rok vydání: | 2018 |
Předmět: |
Cartilage
Articular Hydrodynamic radius Polymers Surface Properties 02 engineering and technology 010402 general chemistry Protective Agents 01 natural sciences Catalysis Osteoarthritis medicine Side chain Copolymer Animals Humans Collagenases Serum Albumin Lubricants chemistry.chemical_classification Chemistry 010405 organic chemistry Cartilage General Chemistry Polymer General Medicine 021001 nanoscience & nanotechnology 0104 chemical sciences medicine.anatomical_structure Chemical engineering Polyglutamic Acid Lubrication Quartz Crystal Microbalance Techniques Surface modification Cattle Adsorption 0210 nano-technology Macromolecule |
Popis: | Tissue-reactive graft copolymers were designed to protect the cartilage against enzymatic degradation and restore its lubrication properties during the early stages of osteoarthritis (OA). The copolymers feature a poly(glutamic acid) (PGA) backbone bearing hydroxybenzaldehyde (HBA) functions and cyclic poly(2-methyl-2-oxazoline) (PMOXA) side chains. PGA-PMOXA-HBA species chemisorb on the degraded tissue via Schiff bases and expose the biopassive and lubricious PMOXA cyclic grafts at the interface. The smaller hydrodynamic radius by cyclic PMOXA side chains coupled to the intrinsic absence of chain ends generate denser and more lubricious films on cartilage when compared to those produced by copolymers bearing linear PMOXA. Topology effects demonstrate how the introduction of cyclic polymers within tissue-reactive copolymers substantially improve their tribological and biopassive properties, suggesting a plethora of possible applications for cyclic macromolecules in biomaterials formulations. |
Databáze: | OpenAIRE |
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