c-Jun Regulates Eyelid Closure and Skin Tumor Development through EGFR Signaling
| Autor: | Erwin F. Wagner, Maria Sibilia, Carsten Frank, Paul Martin, Harald Scheuch, Lukas Kenner, Robert Eferl, Rainer Zenz |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Genetically modified mouse
Skin Neoplasms Heparin-binding EGF-like growth factor Transgene Apoptosis Mice Transgenic Biology Models Biological General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Mice 0302 clinical medicine Genes jun Epidermal growth factor medicine Animals Genetic Predisposition to Disease Transgenes Molecular Biology 030304 developmental biology 0303 health sciences Epidermis (botany) Epidermal Growth Factor Papilloma c-jun Eyelids Gene Expression Regulation Developmental Cell Biology ErbB Receptors Gene Expression Regulation Neoplastic medicine.anatomical_structure Epidermal Cells 030220 oncology & carcinogenesis Immunology Cancer research Carcinogens Intercellular Signaling Peptides and Proteins Tetradecanoylphorbol Acetate Signal transduction Epidermis Keratinocyte Cell Division Heparin-binding EGF-like Growth Factor Signal Transduction Developmental Biology |
| Zdroj: | Developmental Cell. 4(6):879-889 |
| ISSN: | 1534-5807 |
| DOI: | 10.1016/s1534-5807(03)00161-8 |
| Popis: | To investigate the function of c-Jun during skin development and skin tumor formation, we conditionally inactivated c-jun in the epidermis. Mice lacking c-jun in keratinocytes (c-jun(Deltaep)) develop normal skin but express reduced levels of EGFR in the eyelids, leading to open eyes at birth, as observed in EGFR null mice. Primary keratinocytes from c-jun(Deltaep) mice proliferate poorly, show increased differentiation, and form prominent cortical actin bundles, most likely because of decreased expression of EGFR and its ligand HB-EGF. In the absence of c-Jun, tumor-prone K5-SOS-F transgenic mice develop smaller papillomas, with reduced expression of EGFR in basal keratinocytes. Thus, using three experimental systems, we show that EGFR and HB-EGF are regulated by c-Jun, which controls eyelid development, keratinocyte proliferation, and skin tumor formation. |
| Databáze: | OpenAIRE |
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