Network-targeted cerebellar transcranial magnetic stimulation improves attentional control
| Autor: | Mark A. Halko, Hidefusa Okabe, Simon Laganiere, Michael Esterman, Michelle Thai, Elyana Saad, Joseph DeGutis |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Cognitive Neuroscience medicine.medical_treatment Stimulation 050105 experimental psychology Article 03 medical and health sciences Young Adult 0302 clinical medicine Continuous performance task Task-positive network Cerebellum Neural Pathways medicine Humans 0501 psychology and cognitive sciences Attentional blink Attention Default mode network medicine.diagnostic_test 05 social sciences Attentional control Magnetic Resonance Imaging Transcranial Magnetic Stimulation Transcranial magnetic stimulation Neurology Brain stimulation Female Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | NeuroImage. 156 |
| ISSN: | 1095-9572 |
| Popis: | Developing non-invasive brain stimulation interventions to improve attentional control is extremely relevant to a variety of neurological and psychiatric populations, yet few studies have identified reliable biomarkers that can be readily modified to improve attentional control. One potential biomarker of attention is functional connectivity in the core cortical network supporting attention - the dorsal attention network (DAN). We used a network-targeted cerebellar transcranial magnetic stimulation (TMS) procedure, intended to enhance cortical functional connectivity in the DAN. Specifically, in healthy young adults we administered intermittent theta burst TMS (iTBS) to the midline cerebellar node of the DAN and, as a control, the right cerebellar node of the default mode network (DMN). These cerebellar targets were localized using individual resting-state fMRI scans. Participants completed assessments of both sustained (gradual onset continuous performance task, gradCPT) and transient attentional control (attentional blink) immediately before and after stimulation, in two sessions (cerebellar DAN and DMN). Following cerebellar DAN stimulation, participants had significantly fewer attentional lapses (lower commission error rates) on the gradCPT. In contrast, stimulation to the cerebellar DMN did not affect gradCPT performance. Further, in the DAN condition, individuals with worse baseline gradCPT performance showed the greatest enhancement in gradCPT performance. These results suggest that temporarily increasing functional connectivity in the DAN via network-targeted cerebellar stimulation can enhance sustained attention, particularly in those with poor baseline performance. With regard to transient attention, TMS stimulation improved attentional blink performance across both stimulation sites, suggesting increasing functional connectivity in both networks can enhance this aspect of attention. These findings have important implications for intervention applications of TMS and theoretical models of functional connectivity. |
| Databáze: | OpenAIRE |
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