Frontiers of optofluidics in synthetic biology
| Autor: | Philip R. LeDuc, Shih-Jie Lo, Chao-Min Cheng, Cheemeng Tan |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
education.field_of_study
Optics and Photonics Miniaturization Bacteria Population Optical measurements Biomedical Engineering Proteins Bioengineering Nanotechnology General Chemistry Biology Microfluidic Analytical Techniques Biochemistry Optofluidics Synthetic biology Synthetic gene Proteins metabolism Fluorescence Resonance Energy Transfer Enhanced sensitivity RNA Synthetic Biology education Protein network Fluorescent Dyes |
| Zdroj: | Lab on a chip. 12(19) |
| ISSN: | 1473-0189 |
| Popis: | The development of optofluidic-based technology has ushered in a new era of lab-on-a-chip functionality, including miniaturization of biomedical devices, enhanced sensitivity for molecular detection, and multiplexing of optical measurements. While having great potential, optofluidic devices have only begun to be exploited in many biotechnological applications. Here, we highlight the potential of integrating optofluidic devices with synthetic biological systems, which is a field focusing on creating novel cellular systems by engineering synthetic gene and protein networks. First, we review the development of synthetic biology at different length scales, ranging from single-molecule, single-cell, to cellular population. We emphasize light-sensitive synthetic biological systems that would be relevant for the integration with optofluidic devices. Next, we propose several areas for potential applications of optofluidics in synthetic biology. The integration of optofluidics and synthetic biology would have a broad impact on point-of-care diagnostics and biotechnology. |
| Databáze: | OpenAIRE |
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