Retrospective review of unintentional pediatric ingestions of doxylamine
| Autor: | Michael McKinley, Mariam Qozi, Alycia K Clark, F. Lee Cantrell |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty medicine.medical_treatment Antidotes Poison control Toxicology Risk Assessment California Risk Factors Tachycardia Injury prevention medicine Humans Retrospective Studies Retrospective review Dose-Response Relationship Drug Doxylamine business.industry Poisoning Diphenhydramine Age Factors Infant General Medicine Treatment Outcome Anesthesia Accidents Charcoal Child Preschool Toxicity Maximum dose Histamine H1 Antagonists Antihistamine Female Sleep Stages business medicine.drug |
| Zdroj: | Clinical toxicology (Philadelphia, Pa.). 53(3) |
| ISSN: | 1556-9519 |
| Popis: | Doxylamine is a first-generation antihistamine similar in structure to diphenhydramine. Unlike diphenhydramine, however, there is a paucity of data regarding the risk of toxicity following unintentional exposures in pediatric patients.We performed an observational case series with data collected retrospectively from a poison system database for all single-substance pediatric (5 years-old and younger) doxylamine ingestions for the period of 1997-2012. Data collected included age, gender, weight, reason for exposure, exact or estimated maximum dose, clinical effects and medical interventions.A total of 140 cases were identified; 74 (53%) involved males. Ages ranged 6 months to 5 years. In 30 cases (21%), the exact amount ingested was documented and ranged from 6.25-50 mg with a maximum weight-based dose of 6.2 mg/kg. In 76 cases, the estimated maximum dose ranged from 12.5 to 375 mg with a maximum weight-based dose of 37 mg/kg. All symptoms were mild and self-limiting. The only documented intervention was the administration of activated charcoal in 13 cases.Unintentional isolated pediatric doxylamine ingestions did not result in significant toxicity in our 140 cases. Reported doses of up to 6.2 mg/kg resulted in only transient drowsiness and tachycardia. |
| Databáze: | OpenAIRE |
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