Subarachnoid Serotonergic and Noradrenergic Antagonists increase the Pain Response in Rats

Autor: Hazem Adel Ashmawi, Oscar César Pires, Naira Correa Cusma Pelogia, Elton Constantino, Irimar de Paula Posso
Přispěvatelé: ASHMAWI, HAZEM https://orcid.org/0000-0003-0957-971X, ASHMAWI, HAZEM/H-3825-2013
Rok vydání: 2011
Předmět:
Male
medicine.medical_specialty
Formalin Test
ANATOMIA
Espacio subaracnoideo
Central nervous system
Methysergide
Pain
Inhibitory postsynaptic potential
Serotonergic
Subarachnoid Space
ANIMALE
Ratones
Antinociception
Phentolamine
Models
Anesthesiology
Internal medicine
medicine
Animals
FÁRMACO
Vasodilatadores: fentolamina
metisergida
Rats
Wistar
Interphase
Adrenergic alpha-Antagonists
DOLOR
Aguda
Avaliación
Pain Measurement
Inhibition
Pain measurement
ANATOMIA
Espaço subaracnoideo
Behavior
DROGAS
Vasodilatadores: fentolamina
metissergida
ANIMAL
Rato
business.industry
Nociceptors
5-Hydroxytryptamine
Spinal cord
Rats
Anesthesiology and Pain Medicine
medicine.anatomical_structure
Endocrinology
Nociception
Anesthesia
Serotonin Antagonists
Involvement
DOR: Agúda
Avaliação
Subarachnoid space
business
medicine.drug
Zdroj: Web of Science
Repositório Institucional da UNITAU
Universidade de Taubaté (UNITAU)
instacron:UNITAU
ISSN: 0034-7094
DOI: 10.1016/s0034-7094(11)70024-1
Popis: Made available in DSpace on 2019-09-12T16:57:13Z (GMT). No. of bitstreams: 0 Previous issue date: 2011 Pires OC, Ashmawi HA, Constantino E, Pelogia NCC, Posso IP Subarachnoid Serotonergic and Noradrenergic Antagonists Increase the Pain Response in Rats. Background and objectives: There is evidence that the passage of nociceptive information through the posterior horn of the spinal cord (PHSC) on its way to rostral levels of the central nervous system undergoes profound excitatory and inhibitory influences. The objective of the present study was to compare the effects of the subarachnoid administration of methysergide, phentolamine, and phentolamine associated with methysergide on phases I, intermediate, and II of the modified phormaline test in rats. Methods: Twenty-eight male Wistar rats distributed randomly in four groups (n = 7) to received subarachnoid saline solution (GC), phentolamine (GF), methysergide (GM), or phentolamine associated with methysergide (GFM). Pain was induced by the administration of phormaline in the dorsal region of the right hind paw. The test was divided in three phases: phase I, intermediate, and phase II. Statistical analysis of the results was performed using the software SPSS (Statistical Package for Social Sciences), adopting a level of significance of 5%. Results: In the intermediate phase the number of paw elevations was significantly higher in GF, GM, and GFM groups when compared to the GC group. Conclusions: The results suggest the existence of a noradrenergic and serotonergic effect in the inhibitory descending system of acute pain, with the possibility of using serotonergic and alpha 1-adrenergic antagonists to control acute pain. [Pires, Oscar Cesar; Ashmawi, Hazem Adel; Constantino, Elton; Cusma Pelogia, Naira Correa; Posso, Irimar de Paula] Universidade de Taubaté (Unitau), Inst Basico Biociencias, Sao Paulo, Brazil
Databáze: OpenAIRE
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