Effect of maternal diabetes on female offspring
| Autor: | Mauricio Isaac Panicio, Guiomar Nascimento Gomes, Juliana Oliveira Martins, Marcos Paulo Suehiro Dantas |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Time Factors
Pregnancy in Diabetics Streptozocin/administration & dosage lcsh:Medicine Urine Kidney chemistry.chemical_compound Pregnancy Reference Values Urea Diabetic Nephropathies Diabetes mellitus experimental Proteinuria Artigo Original Ureia General Medicine Fetal development Prenatal Exposure Delayed Effects Creatinine Hypertension Female Original Article Creatinina medicine.symptom Glomerular Filtration Rate medicine.medical_specialty Offspring Diabetes mellitus experimental Estreptozocina/administração & dosagem Prenhez Renal function Gestational Age Streptozocin Diabetes Mellitus Experimental Diabetes mellitus Internal medicine medicine Animals Rats Wistar business.industry lcsh:R medicine.disease Desenvolvimento fetal Disease Models Animal Blood pressure Endocrinology chemistry Pregnancy animal Hyperglycemia business Hipertensão |
| Zdroj: | einstein (São Paulo) v.12 n.4 2014 Einstein (São Paulo) Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE) instacron:IIEPAE Einstein Einstein (São Paulo), Vol 12, Iss 4, Pp 413-419 |
| Popis: | Objective To evaluate the effect of maternal diabetes on the blood pressure and kidney function of female offspring, as well as if such changes exacerbate during pregnancy.MethodsDiabetes mellitus was induced in female rats with the administration of streptozotocin in a single dose, one week before mating. During pregnancy, blood pressure was measured through plethysmography. On the 20th day of pregnancy, the animals were placed for 24 hours in metabolic cages to obtain urine samples. After the animals were removed from the cages, blood samples were withdrawn. One month after pregnancy, new blood and urine sample were collected. Kidney function was evaluated through proteinuria, plasma urea, plasma creatinine, creatinine excretion rate, urinary flow, and creatinine clearance.Results The female offspring from diabetic mothers showed an increase in blood pressure, and a decrease in glomerular filtration rate in relation to the control group.Conclusion Hyperglycemia during pregnancy was capable of causing an increase in blood pressure and kidney dysfunction in the female offspring. |
| Databáze: | OpenAIRE |
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