Drebrin promotes lung adenocarcinoma cell migration through inducing integrin β1 endocytosis

Autor:	Qiaoyan Yu, Feiyu Tang, Fuyang Cao, Xiyan Tan, Liang Weng, Lunquan Sun
Rok vydání:	2022
Předmět:	Lung Neoplasms Integrin beta1 Neuropeptides Biophysics Adenocarcinoma of Lung Cell Biology Biochemistry Endocytosis Gene Expression Regulation Neoplastic Cell Movement Cell Line Tumor Humans Molecular Biology Cell Proliferation
Zdroj:	Biochemical and Biophysical Research Communications. 630:175-182
ISSN:	0006-291X
Popis:	Lung adenocarcinoma (LUAD) is the most common type of lung cancers, which remains the leading cause of cancer-related death worldwide. Drebrin can promote cell migration and invasion with poor prognosis, but its roes in LUAD tumor progression remains unknown. We showed that the expression of Drebrin was upregulated in clinical LUAD samples. A Kaplan-Meier survival analysis showed that a high expression of Drebrin predicated poor prognosis in LUAD. In vitro, Drebrin promoted anchorage-independent growth and migration of LUAD cells. Drebrin interacted with dynamin through CT domain, and served as an adaptor to promote LUAD cell migration through inducing integrin β1 endocytosis. Thus, this study demonstrated the critical role of Drebrin in LUAD and associated mechanism.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::778e83b006fd2030a137f592ee9ca5f3 https://doi.org/10.1016/j.bbrc.2022.09.050 Zobrazit plný text záznamu Full Text from ScienceDirect