Purine–Purine Base Pairs in Parallel DNA: β-D Anomeric 8-Aza-7-deazaisoguanine and 7-Functionalized Conjugates Form Stable Base Pairs with α-D 5-Aza-7-deaza-2′-deoxyguanosine

Autor:	Aigui Zhang, Dasharath Kondhare, Peter Leonard, Frank Seela
Rok vydání:	2022
Předmět:	Pharmacology Purines Organic Chemistry Biomedical Engineering Nucleic Acid Conformation Pharmaceutical Science Bioengineering DNA Base Pairing Biotechnology
Zdroj:	Bioconjugate Chemistry. 33:1796-1802
ISSN:	1520-4812 1043-1802
Popis:	Anomeric purine-purine DNA represents a new recognition system with strands in parallel orientation. This work investigates the new heterochiral system and the positional impact of nucleobase functionalization. Tracts of anomeric isoguanine/8-aza-7-deazaisoguanine base pairs with 5-aza-7-deazaguanine were embedded in anomeric Watson-Crick DNA. It was discovered that stable purine-purine base pairs are formed in anomeric DNA. Nucleobase functionalization of the novel base pair system with short ethynyl and bulky octadiynyl chains showed that the position of functionalization is critical. From
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::778dab658fa4669955a4001b25c26838 https://doi.org/10.1021/acs.bioconjchem.2c00387 Zobrazit plný text záznamu