Alport's syndrome: risk of glomerulonephritis induced by anti-glomerular-basement-membrane antibody after renal transplantation
| Autor: | Clyne Dh, First Mr, Mark A. Weiss, N. C. Mendoza, Alexander Jw, Shah B |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Adult
Graft Rejection Male Kidney Glomerulus Nephritis Hereditary urologic and male genital diseases Immunoglobulin E Antibodies Basement Membrane Glomerulonephritis Medicine Humans Transplantation Homologous Kidney S syndrome biology urogenital system business.industry medicine.disease Kidney Transplantation female genital diseases and pregnancy complications Transplantation Glomerular basement membrane Antibody medicine.anatomical_structure Immunoglobulin G Immunology biology.protein Antibody business |
| Zdroj: | Nephron. 50(1) |
| ISSN: | 1660-8151 |
| Popis: | Two patients with Alport's syndrome developed glomerulonephritis induced by anti-glomerular-basement-membrane (anti-GBM) antibody after renal transplantation. One patient presented at 5 months after transplantation the second patient 18 months after transplantation. Both grafts failed and the patients returned to dialysis. Our observations suggest that the patients with Alport's syndrome are at risk of developing anti-GBM antibody type glomerulonephritis in the transplanted kidney. This does not occur in the early period after transplantation, probably because of heavy immunosuppression. |
| Databáze: | OpenAIRE |
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