Corymbulosins D–H, 2-Hydroxy- and 2-Oxo-clerodane Diterpenes from the Bark of Laetia corymbulosa
| Autor: | Yohei Saito, Shuichi Fukuyoshi, Barry R. O'Keefe, Kyoko Nakagawa-Goto, Kuo Hsiung Lee, Masuo Goto, David J. Newman, Airi Suzuki, Katsunori Miyake |
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| Rok vydání: | 2017 |
| Předmět: |
Salicaceae
Stereochemistry Pharmaceutical Science 01 natural sciences Article Diterpenes Clerodane Analytical Chemistry chemistry.chemical_compound Peru Drug Discovery Humans Laetia Nuclear Magnetic Resonance Biomolecular Pharmacology Molecular Structure biology 010405 organic chemistry Organic Chemistry Hydroxy group biology.organism_classification Antineoplastic Agents Phytogenic 0104 chemical sciences 010404 medicinal & biomolecular chemistry Complementary and alternative medicine chemistry visual_art Plant Bark visual_art.visual_art_medium Clerodane Diterpenes Molecular Medicine Bark Drug Screening Assays Antitumor Two-dimensional nuclear magnetic resonance spectroscopy Human cancer |
| Zdroj: | Journal of Natural Products. 80:1065-1072 |
| ISSN: | 1520-6025 0163-3864 |
| Popis: | A bioactive CH3OH–CH2Cl2 (1:1) extract of the bark of Laetia corymbulosa provided five new clerodane diterpenes with an isozuelanin skeleton, designated as corymbulosins D–H (1–5), as well as the known corymbulosins B (6) and C (7), for which the relative configurations were not previously determined. The structures of 1–5 were characterized on the basis of 1D and 2D NMR spectroscopic and HRMS analysis. The absolute configurations of all isolated compounds 1–7 were verified through chemical methods, including modified Mosher esterifications or oxidation of the hydroxy group at C-2, ECD experiments, and spectroscopic data comparison. The isolated compounds were evaluated for antiproliferative activity against a small panel of human cancer cell lines. |
| Databáze: | OpenAIRE |
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