Association of Psoriasis Severity with Serum Prolactin, Thyroid Hormones, and Cortisol before and after Treatment
| Autor: | Parviz Toossi, Reza M. Robati, Ehsan Abolhasani, Nastaran Namazi, Shima Younespour, Sara Khalilazar, Mohammad Rahmati-Roodsari |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Thyroid Hormones medicine.medical_specialty endocrine system Hydrocortisone endocrine system diseases Article Subject lcsh:Medicine lcsh:Technology General Biochemistry Genetics and Molecular Biology Serum prolactin Thyroid-stimulating hormone Psoriasis Area and Severity Index Internal medicine Psoriasis medicine Humans lcsh:Science Aged General Environmental Science lcsh:T business.industry lcsh:R General Medicine Middle Aged medicine.disease Prolactin Treatment Outcome Endocrinology Case-Control Studies Thyroid hormones Female lcsh:Q business After treatment hormones hormone substitutes and hormone antagonists Research Article Hormone |
| Zdroj: | The Scientific World Journal, Vol 2013 (2013) The Scientific World Journal |
| DOI: | 10.1155/2013/921819 |
| Popis: | Background. Prolactin (PRL) level is proposed to be associated with the severity of psoriasis although the previous studies reported different results.Objective. To find the association between PRL levels and severity of psoriasis before and after treatment. In addition, we aimed to find a difference in prolactin, thyroid stimulating hormone (TSH), thyroid hormones (T3and T4), and cortisol levels between patients with psoriasis and normal controls.Methods. First, the levels of hormones were measured in 30 patients with psoriasis and 30 matched controls. The severity was assessed by psoriasis area and severity index (PASI). Then, patients were treated, and PASI was assessed every week until achieving PASI-75 response. At this time, the hormones were measured again and compared to the baseline.Results. No statistical significant difference was observed in the mean PRL, T3, T4, TSH, and cortisol levels between cases and controls. Comparing to the baseline, a significant decrease in PRL levels and a significant increase in T3and serum cortisol levels were observed after treatment (P<0.05), while the changes in other hormones were not significant.Conclusion. After treatment, PRL significantly decreased, and T3and cortisol levels significantly increased. No correlation between hormone levels and improvement of PASI score existed. |
| Databáze: | OpenAIRE |
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