No Association of an Interleukin 4 Gene Promoter Polymorphism with Graves' Disease in the United Kingdom
| Autor: | R. Nithiyananthan, S. C. L. Gough, S. M. Gibson, Amit Allahabadia, Jayne A. Franklyn, Joanne M. Heward |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
medicine.medical_specialty
Genotype Graves' disease Endocrinology Diabetes and Metabolism Clinical Biochemistry Biology Polymerase Chain Reaction Biochemistry Genetic determinism White People Cohort Studies Endocrinology Gene Frequency Reference Values Internal medicine medicine Humans Point Mutation Allele Promoter Regions Genetic Interleukin 4 Alleles Genetics Autoimmune disease Polymorphism Genetic Biochemistry (medical) Chromosome Mapping Promoter DNA medicine.disease Graves Disease United Kingdom Case-Control Studies Immunology Interleukin-4 Restriction fragment length polymorphism Chromosomes Human Pair 18 Polymorphism Restriction Fragment Length |
| Zdroj: | Journal of Clinical Endocrinology & Metabolism. 86:3861-3863 |
| ISSN: | 0021-972X |
| DOI: | 10.1210/jc.86.8.3861 |
| Popis: | Graves' disease (GD) is an autoimmune thyroid disease of unknown etiology, although predisposition to the development of this disease is thought to be caused by both genetic and environmental factors. Recently, an association between a promoter polymorphism of the interleukin 4 gene and GD has been reported. A C-T base change at position -590 showed modest protection against the development of GD in a United Kingdom data set of 135 patients with GD and 101 controls. This polymorphism was, therefore, investigated in a much larger case-control cohort of 384 patients with GD and 288 control subjects using PCR, followed by restriction fragment length polymorphism analysis. No protective effect of the T allele of this polymorphism was observed in our data set, and indeed no significant difference in either allelic or genotypic distribution was seen between the patient and control groups. Moreover, calculation of probabilities indicate that the original study lacked sufficient power to support the conclusions drawn. Our data support the hypothesis that the C-T promoter polymorphism of the interleukin 4 gene does not confer protection against the development of GD in Caucasians in the United Kingdom. |
| Databáze: | OpenAIRE |
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