Involvement of T lymphocytes in the placentae with villitis of unknown etiology from pregnancies complicated with preeclampsia
| Autor: | Zdeslav Benzon, Sandra Benzon, Sandra Zekic Tomas, Marko Vulić, Ivana Kuzmić Prusac |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Adult CD4-Positive T-Lymphocytes Pathology medicine.medical_specialty Placenta Diseases CD3 Placenta Preeclampsia 03 medical and health sciences 0302 clinical medicine T-Lymphocyte Count Pre-Eclampsia Pregnancy Preeclampsia T lymphocytes villitis of unknown etiology medicine Humans IL-2 receptor Inflammation 030219 obstetrics & reproductive medicine biology business.industry Obstetrics and Gynecology medicine.disease 030104 developmental biology medicine.anatomical_structure Case-Control Studies Pediatrics Perinatology and Child Health biology.protein Immunohistochemistry Chorionic villi Female Chorionic Villi business Villitis of unknown etiology CD8 |
| Zdroj: | The journal of maternal-fetalneonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 29(7) |
| ISSN: | 1476-4954 |
| Popis: | Translator disclaimer Abstract Objective: The aim of the study was to compare immunohistochemical expression of different T type lymphocytes in foci of villitis of placentae with villitis of unknown etiology (VUE) without and with preeclampsia (PE). Methods: Fifty-four placentae were collected from women who had VUE with (N = 27) and without (N = 27) PE. Immunohistochemistry for types of T lymphocytes was performed on formalin fixed and paraffin-embedded sections by use of the CD3, CD4, FOXP3, CD25, CD8 and CD68 antibodies. All data analyses were done by R Development Core Team. Results: There was higher immunohistochemical CD4 positive T lymphocyte count and CD4 positive/CD8 positive ratio in placentae with VUE complicated with PE compared to control group. Conclusion: The higher immunohistochemical CD4 positive T lymphocyte count and CD4 positive/CD8 positive ratio in placentae with VUE complicated with PE could point to their role in ethiopathogenesis of PE. |
| Databáze: | OpenAIRE |
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