Abnormalities detected on transvaginal ultrasonography in tamoxifen-treated postmenopausal breast cancer patients may represent endometrial cystic atrophy
| Autor: | Steven A. Vasilev, Sara L. Shaw, Subir Roy, Tamara Odom-Maryon, Jean F. Simpson, Kathryn F. McGonigle |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
medicine.medical_specialty Antineoplastic Agents Hormonal medicine.medical_treatment Breast Neoplasms Endometrium Hysterectomy Curettage Breast cancer Polyps medicine Endometrial Polyp Humans Aged Retrospective Studies Ultrasonography Gynecology Aged 80 and over Uterine Diseases business.industry Cysts Endometrial cancer Obstetrics and Gynecology Hyperplasia Middle Aged medicine.disease Postmenopause Tamoxifen medicine.anatomical_structure Adenocarcinoma Female Atrophy business medicine.drug |
| Zdroj: | American journal of obstetrics and gynecology. 178(6) |
| ISSN: | 0002-9378 |
| Popis: | OBJECTIVE: This study was conducted to examine the histopathologic changes in tamoxifen-treated postmenopausal patients with endometrial thickness ≥5 mm with transvaginal ultrasonography. STUDY DESIGN: Thirty-five tamoxifen-treated postmenopausal breast cancer patients underwent transvaginal pelvic ultrasonography with endometrial thickness ≥5 mm followed by either curettage-hysteroscopy ( n = 24), or hysterectomy ( n = 11). Endometrial histopathologic findings were examined. RESULTS: Overall, endometrial polyps were the most common histopathologic finding (23 of 35 patients). Endometrial cystic atrophy was uncommonly detected in patients undergoing curettage-hysteroscopy (1 of 24 patients) compared with patients undergoing hysterectomy (9 of 11 patients). No cases of endometrial cancer or hyperplasia were detected. CONCLUSIONS: Endometrial polyps were a frequent finding in tamoxifen-treated postmenopausal women who had endometrial thickness ≥5 mm with the use of transvaginal ultrasonography. Endometrial cystic atrophy may explain "thickened endometrium" on transvaginal ultrasonography in this patient population with no evidence of endometrial polyps, hyperplasia, or adenocarcinoma after surgical evaluation. (Am J Obstet Gynecol 1998;178:1145-50.) |
| Databáze: | OpenAIRE |
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