Losartan prevents mesenteric vascular bed alterations in high-fat diet fed rats
| Autor: | Silvana M. Cantú, H. A. Peredo, Ana María Puyó, A. S. Donoso, Marcelo Roberto Choi, H.J. Lee, María Álvarez Primo |
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| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Adipose tissue Blood Pressure 030204 cardiovascular system & hematology Diet High-Fat Losartan Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Insulin resistance Internal medicine medicine Animals Mesentery Pharmacology (medical) Endothelial dysfunction Antihypertensive Agents Adiposity Angiotensin II receptor type 1 business.industry medicine.disease Angiotensin II Rats 030104 developmental biology Blood pressure Endocrinology Adipose Tissue Prostaglandins Insulin Resistance Metabolic syndrome Cardiology and Cardiovascular Medicine business Angiotensin II Type 1 Receptor Blockers medicine.drug |
| Zdroj: | Clínica e Investigación en Arteriosclerosis. 33:1-9 |
| ISSN: | 0214-9168 |
| DOI: | 10.1016/j.arteri.2020.06.004 |
| Popis: | Dysfunction of perivascular adipose tissue of mesenteric bed participates in the pathophysiology of high blood pressure linked to metabolic syndrome. Thus, it might consider a new therapeutic objective to take account in cardiovascular and metabolic diseases. Besides its antihypertensive effect, there is a growing interest on the pleiotropic actions of losartan, an angiotensin II type 1 (AT1) receptor antagonist. The aim of the study was to analyze the actions of losartan treatment on adiposity index and prostanoids release from mesenteric vascular bed and its relationship with blood pressure as well as homeostasis model of assessment of insulin resistance (HOMA-IR) in Sprague-Dawley rats under a high-fat (HF) diet for 8 weeks. Four groups were used: control (C), HF diet (HF, 50%, w/w bovine fat), losartan-treated (CL8, 30mg/kg/body weight/day in the drinking water) and losartan-treated HF diet (HFL, both treatments). A high-fat diet incremented systolic blood pressure, HOMA-IR, adiposity of mesenteric vascular bed and the release of vasoconstrictor prostanoids such as thromboxane (TX) B2 and prostaglandin (PG) F2α as well as PGE2, an inflammatory prostanoid in a context of insulin resistance and hypertension. We found a positive correlation between adiposity index and systolic blood pressure. Also, both parameters are positive correlated with the HOMA IR index. Moreover, we also found that these prostanoids release correlate with systolic blood pressure as well as with mesenteric vascular bed adiposity index. Losartan treatment prevented all these alterations and normalized the PGI2/TXA2 ratio in high-fat fed rats. We conclude that losartan may play beneficial actions on perivascular adipose tissue alterations and endothelial dysfunction through restoration of normal balance of vasoactive substances in this model. |
| Databáze: | OpenAIRE |
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