Global Dynamics and Implications of an HBV Model with Proliferating Infected Hepatocytes
| Autor: | Steffen E. Eikenberry, Sarah Hews, John D. Nagy, Tin Phan, Yang Kuang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Technology
QH301-705.5 QC1-999 ratio-dependent transformation Disease Biology Stability result Chronic hepatitis medicine HBV General Materials Science Hopf bifurcation Biology (General) Instrumentation QD1-999 Fluid Flow and Transfer Processes logistic hepatocyte growth Process Chemistry and Technology Physics Dynamics (mechanics) General Engineering Liver failure Engineering (General). Civil engineering (General) Computer Science Applications Chronic infection Chemistry medicine.anatomical_structure Hepatocyte Immunology origin stability TA1-2040 Viral load |
| Zdroj: | Applied Sciences, Vol 11, Iss 8176, p 8176 (2021) Applied Sciences Volume 11 Issue 17 |
| ISSN: | 2076-3417 |
| Popis: | Chronic hepatitis B (HBV) infection is a major cause of human suffering, and a number of mathematical models have examined the within-host dynamics of the disease. Most previous models assumed that infected hepatocytes do not proliferate however, the effect of HBV infection on hepatocyte proliferation is controversial, with conflicting data showing both induction and inhibition of proliferation. With a family of ordinary differential equation (ODE) models, we explored the dynamical impact of proliferation among HBV-infected hepatocytes. Here, we show that infected hepatocyte proliferation in this class of models generates a threshold that divides the dynamics into two categories. Sufficiently compromised proliferation in infected cells produces complex dynamics characterized by oscillating viral loads, whereas higher proliferation generates straightforward dynamics that always results in chronic infection, sometimes with liver failure. A global stability result of the liver failure state was included as it is unique to this class of models. Finally, the model analysis motivated a testable biological hypothesis: Healthy hepatocytes are present in chronic HBV infection if and only if the proliferation of infected hepatocytes is severely impaired. |
| Databáze: | OpenAIRE |
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