Hoffman's syndrome: pseudohypertrophic myopathy as initial manifestation of hypothyroidism. Case report
| Autor: | Luiz Felipe Rocha Vasconcellos, Maria Claudia Peixoto, Tatiana Oliveira, Glória Maria Cardoso de Andrade Penque, Ana Claudia Celestino Leite |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2003 |
| Předmět: |
myalgia
Adult Male musculoskeletal diseases medicine.medical_specialty Weakness endocrine system Adult male endocrine system diseases Neurosciences. Biological psychiatry. Neuropsychiatry Muscular Cramps Autoimmune Diseases lcsh:RC321-571 Muscular Diseases Internal medicine medicine Humans Myopathy Facial edema Muscle Skeletal lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry S syndrome business.industry Hypertrophy Syndrome body regions Endocrinology Neurology pseudohypertrophy Neurology (clinical) hypothyroidism medicine.symptom business RC321-571 Hormone myopathy |
| Zdroj: | Arquivos de Neuro-Psiquiatria, Vol 61, Iss 3B, Pp 851-854 (2003) Arquivos de Neuro-Psiquiatria v.61 n.3B 2003 Arquivos de neuro-psiquiatria Academia Brasileira de Neurologia instacron:ABNEURO |
| ISSN: | 1678-4227 |
| Popis: | The frequency of myopathy in hypothyroidism ranges from 30 to 80%. The major symptoms related are weakness, muscular cramps and myalgia. The pseudohyperthrophic form is called Hoffman's syndrome. The electrophysiological study reveals myopathy, neuropathy or mixed pattern. Laboratorial investigation generally shows increased levels of muscle enzymes and low serum thyroid hormones, with thyrotrophic-stimulating hormone (TSH) elevated. The treatment consists in hormone replacement and the prognosis is good in most of the cases. We report an adult male who developed muscular cramps, myalgia, weakness, pseudohyperthrophy, associated with facial edema and alteration of his voice. The muscle enzymes were increased and T4 was undetectable with a raised level of TSH. The myopathy was the initial manifestation of hypothyroidism in this case. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|